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• W2032022513 abstract "Summary Intravenous infusion of E. coli endotoxin at a rate of 4.16 ng/kg/min over 6 hr (total dose 1.5 μg/kg) in 5 cows in the first trimester of gestation induced abortion between 60 and 72 hr in three cows. Plasma PGF 2α levels in the aborting cows increased significantly to 289% of the zero time control (ZTC) at 1 hr and remained elevated for 9hr. The PGF 2α level remained unaffected in the non‐aborting cows except at 2 hr. The plasma TxB 2 levels were increased by 6 to 18 fold for 6 hr in both the aborting and non‐aborting cows relative to their ZTC controls. The 6‐keto‐PGF 1α levels were significantly increased to 2 to 3 fold only in the aborting cows. Plasma cortisol levels were increased maximally to 1,500% of ZTC at 5 hr in the aborting cows. Thereafter, the levels gradually declined but remained significantly elevated for 24 hr. The increases in the cortisol levels in the non‐aborting cows were only 280% of ZTC at 5 hr and returned to ZTC value by 12 hr. Plasma progesterone levels in the aborting cows remained unaffected until 12 hr followed by a progressive decline through 18 hr to extremely low levels at 3, 4, and 5 days. Endotoxin‐infusion caused hyperglycemia in both aborting and non‐aborting cows and lactic acidemia in the aborting cows. Treatment with two doses of flunixin meglumine (FM, 1.1 mg/kg), an inhibitor of cyclooxygenase, 1 hr prior to endotoxin infusion and then 13 hr later, completely prevented the endotoxin‐induced abortion and increases in the plasma PGF 2α , TxB 2 and 6‐keto‐PGF 1α concentrations. The PGE level remained unaffected. Although FM treatment failed to abolish endotoxin‐induced increases in the plasma cortisol and lactic acid levels, it effectively prevented marked decreases in the progesterone and increases in the glucose concentrations. It was concluded that the use of FM offers therapeutic promise in preventing bovine abortion caused by endotoxin resulting from bacterial infection during the 1st trimester of gestation." @default.
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• W2032022513 date "1991-02-12" @default.
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• W2032022513 title "Role of Eicosanoids in Abortion and its Prevention by Treatment with Flunixin Meglumine in Cows During the First Trimester of Pregnancy" @default.
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• W2032022513 doi "https://doi.org/10.1111/j.1439-0442.1991.tb01034.x" @default.
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