Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032024925> ?p ?o ?g. }
- W2032024925 endingPage "1366" @default.
- W2032024925 startingPage "1359" @default.
- W2032024925 abstract "Biological screening of (hetero)aromatic compounds allowed the identification of some novel inhibitors of Aβ1–40 aggregation, bearing indane and indole rings as common scaffolds. Molecular decoration of lead compounds led to inhibitors exhibiting a potency, measured by the Thioflavin T fluorimetric assay, ranging from high to low micromolar IC50. The 2-(p-isopropylphenyldiazenylmethylene)indolone derivative 6c resulted as the most potent aggregation inhibitor exhibiting an IC50 of 1.4 μM, with complete lack of fibril formation as confirmed by transmission electron microscopy. Structure–activity relationships suggested that binding to the Aβ peptide may be largely guided by π-stacking and hydrogen bond interactions." @default.
- W2032024925 created "2016-06-24" @default.
- W2032024925 creator A5009145246 @default.
- W2032024925 creator A5051548402 @default.
- W2032024925 creator A5067557076 @default.
- W2032024925 creator A5082305023 @default.
- W2032024925 creator A5087168657 @default.
- W2032024925 creator A5087208103 @default.
- W2032024925 creator A5087524799 @default.
- W2032024925 creator A5088367752 @default.
- W2032024925 date "2010-04-01" @default.
- W2032024925 modified "2023-10-06" @default.
- W2032024925 title "Design, synthesis and biological evaluation of indane-2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as β-amyloid aggregation inhibitors" @default.
- W2032024925 cites W1487727801 @default.
- W2032024925 cites W1520113561 @default.
- W2032024925 cites W1970602496 @default.
- W2032024925 cites W1983877884 @default.
- W2032024925 cites W1985615487 @default.
- W2032024925 cites W1987398071 @default.
- W2032024925 cites W1995247791 @default.
- W2032024925 cites W1997910595 @default.
- W2032024925 cites W2000535047 @default.
- W2032024925 cites W2002768080 @default.
- W2032024925 cites W2004400100 @default.
- W2032024925 cites W2004784996 @default.
- W2032024925 cites W2007236469 @default.
- W2032024925 cites W2008063169 @default.
- W2032024925 cites W2011436288 @default.
- W2032024925 cites W2013845640 @default.
- W2032024925 cites W2023517321 @default.
- W2032024925 cites W2025022665 @default.
- W2032024925 cites W2026395206 @default.
- W2032024925 cites W2027187941 @default.
- W2032024925 cites W2030547977 @default.
- W2032024925 cites W2048695741 @default.
- W2032024925 cites W2052606445 @default.
- W2032024925 cites W2062444405 @default.
- W2032024925 cites W2076855040 @default.
- W2032024925 cites W2082063369 @default.
- W2032024925 cites W2122595519 @default.
- W2032024925 cites W2134347246 @default.
- W2032024925 cites W2143694002 @default.
- W2032024925 cites W2159879659 @default.
- W2032024925 cites W2161453624 @default.
- W2032024925 cites W2165186407 @default.
- W2032024925 doi "https://doi.org/10.1016/j.ejmech.2009.12.029" @default.
- W2032024925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20137834" @default.
- W2032024925 hasPublicationYear "2010" @default.
- W2032024925 type Work @default.
- W2032024925 sameAs 2032024925 @default.
- W2032024925 citedByCount "49" @default.
- W2032024925 countsByYear W20320249252012 @default.
- W2032024925 countsByYear W20320249252013 @default.
- W2032024925 countsByYear W20320249252014 @default.
- W2032024925 countsByYear W20320249252015 @default.
- W2032024925 countsByYear W20320249252016 @default.
- W2032024925 countsByYear W20320249252017 @default.
- W2032024925 countsByYear W20320249252018 @default.
- W2032024925 countsByYear W20320249252019 @default.
- W2032024925 countsByYear W20320249252020 @default.
- W2032024925 countsByYear W20320249252021 @default.
- W2032024925 countsByYear W20320249252022 @default.
- W2032024925 countsByYear W20320249252023 @default.
- W2032024925 crossrefType "journal-article" @default.
- W2032024925 hasAuthorship W2032024925A5009145246 @default.
- W2032024925 hasAuthorship W2032024925A5051548402 @default.
- W2032024925 hasAuthorship W2032024925A5067557076 @default.
- W2032024925 hasAuthorship W2032024925A5082305023 @default.
- W2032024925 hasAuthorship W2032024925A5087168657 @default.
- W2032024925 hasAuthorship W2032024925A5087208103 @default.
- W2032024925 hasAuthorship W2032024925A5087524799 @default.
- W2032024925 hasAuthorship W2032024925A5088367752 @default.
- W2032024925 hasConcept C112887158 @default.
- W2032024925 hasConcept C142724271 @default.
- W2032024925 hasConcept C178790620 @default.
- W2032024925 hasConcept C179104552 @default.
- W2032024925 hasConcept C185592680 @default.
- W2032024925 hasConcept C192527728 @default.
- W2032024925 hasConcept C202751555 @default.
- W2032024925 hasConcept C21951064 @default.
- W2032024925 hasConcept C2777028628 @default.
- W2032024925 hasConcept C2777456753 @default.
- W2032024925 hasConcept C2777633098 @default.
- W2032024925 hasConcept C2777752112 @default.
- W2032024925 hasConcept C2777752497 @default.
- W2032024925 hasConcept C2778896982 @default.
- W2032024925 hasConcept C2779134260 @default.
- W2032024925 hasConcept C2779953032 @default.
- W2032024925 hasConcept C32909587 @default.
- W2032024925 hasConcept C33347731 @default.
- W2032024925 hasConcept C502032728 @default.
- W2032024925 hasConcept C55493867 @default.
- W2032024925 hasConcept C71240020 @default.
- W2032024925 hasConcept C71924100 @default.
- W2032024925 hasConceptScore W2032024925C112887158 @default.
- W2032024925 hasConceptScore W2032024925C142724271 @default.
- W2032024925 hasConceptScore W2032024925C178790620 @default.
- W2032024925 hasConceptScore W2032024925C179104552 @default.