Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032025122> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W2032025122 abstract "To develop an effective vaccine against multiple genotypes of enterovirus 71 (EV71), we generated chimeric virus-like particles (VLPs) repetitively displaying the common neutralizing epitopes of EV71 and evaluated their immunogenicities in mice. The two conserved epitopes, encompassing amino acids 163-177 and 208-222 of VP1 of EV71, were fused to hepatitis B core antigen (HBcAg) and expressed in E.coli. The resulting fusion proteins were found to assemble into chimeric VLPs. Both unmodified HBcAg and chimeric VLPs induced HBcAg-specific antibody responses in mice, however, only chimeric VLP-immunized sera possessed EV71 epitope-specific IgG antibodies and efficiently neutralized different EV71 strains. Collectively, our results indicate that the chimeric VLP is capable of eliciting broadly neutralizing antibody responses and is therefore a promising EV71 vaccine candidate." @default.
- W2032025122 created "2016-06-24" @default.
- W2032025122 creator A5010719742 @default.
- W2032025122 creator A5040006210 @default.
- W2032025122 creator A5056168495 @default.
- W2032025122 creator A5077274385 @default.
- W2032025122 creator A5087100611 @default.
- W2032025122 date "2011-01-10" @default.
- W2032025122 modified "2023-09-25" @default.
- W2032025122 title "Chimeric virus-like particles presenting common neutralizing epitopes of enterovirus 71" @default.
- W2032025122 doi "https://doi.org/10.1186/1753-6561-5-s1-p29" @default.
- W2032025122 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3019453" @default.
- W2032025122 hasPublicationYear "2011" @default.
- W2032025122 type Work @default.
- W2032025122 sameAs 2032025122 @default.
- W2032025122 citedByCount "0" @default.
- W2032025122 crossrefType "journal-article" @default.
- W2032025122 hasAuthorship W2032025122A5010719742 @default.
- W2032025122 hasAuthorship W2032025122A5040006210 @default.
- W2032025122 hasAuthorship W2032025122A5056168495 @default.
- W2032025122 hasAuthorship W2032025122A5077274385 @default.
- W2032025122 hasAuthorship W2032025122A5087100611 @default.
- W2032025122 hasBestOaLocation W20320251221 @default.
- W2032025122 hasConcept C159047783 @default.
- W2032025122 hasConcept C159654299 @default.
- W2032025122 hasConcept C195616568 @default.
- W2032025122 hasConcept C203014093 @default.
- W2032025122 hasConcept C2522874641 @default.
- W2032025122 hasConcept C2777888124 @default.
- W2032025122 hasConcept C2778889330 @default.
- W2032025122 hasConcept C71924100 @default.
- W2032025122 hasConceptScore W2032025122C159047783 @default.
- W2032025122 hasConceptScore W2032025122C159654299 @default.
- W2032025122 hasConceptScore W2032025122C195616568 @default.
- W2032025122 hasConceptScore W2032025122C203014093 @default.
- W2032025122 hasConceptScore W2032025122C2522874641 @default.
- W2032025122 hasConceptScore W2032025122C2777888124 @default.
- W2032025122 hasConceptScore W2032025122C2778889330 @default.
- W2032025122 hasConceptScore W2032025122C71924100 @default.
- W2032025122 hasIssue "S1" @default.
- W2032025122 hasLocation W20320251221 @default.
- W2032025122 hasLocation W20320251222 @default.
- W2032025122 hasOpenAccess W2032025122 @default.
- W2032025122 hasPrimaryLocation W20320251221 @default.
- W2032025122 hasRelatedWork W1159797674 @default.
- W2032025122 hasRelatedWork W1966345551 @default.
- W2032025122 hasRelatedWork W2000352908 @default.
- W2032025122 hasRelatedWork W2010362710 @default.
- W2032025122 hasRelatedWork W2021304817 @default.
- W2032025122 hasRelatedWork W2043425959 @default.
- W2032025122 hasRelatedWork W2069525108 @default.
- W2032025122 hasRelatedWork W2104321589 @default.
- W2032025122 hasRelatedWork W2230912919 @default.
- W2032025122 hasRelatedWork W2411848931 @default.
- W2032025122 hasVolume "5" @default.
- W2032025122 isParatext "false" @default.
- W2032025122 isRetracted "false" @default.
- W2032025122 magId "2032025122" @default.
- W2032025122 workType "article" @default.