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• W2032025523 abstract "Regulation of MAC-1 (CD11b/CD18) expression on circulating granulocytes in endurance runners. Med. Sci. Sports Exerc., Vol. 31, No. 3, pp. 362-367, 1999. Purpose: We tested the hypothesis that degranulation of granulocytes and upregulation of the granulocyte integrin MA-1 (CD11b/CD18) are related to exercise duration and/or intensity. We also investigated whether or not the expression of MAC-1 would be influenced by body temperature or dehydration. Moreover, we tested the hypothesis that changes in leukocyte counts and changes in MAC1 expression with endurance exercise are independently regulated. Methods: In eight amateur runners, MAC-1 (CD11b/CD18) surface expression on granulocytes was determined by fluorescent antibody cell sorting, before and after an incremental maximal treadmill test, a moderate 3-h run, and a competitive marathon race. Results: Expression CD11b on granulocytes was increased by 10 ± 9.6% (P < 0.05) after the maximal treadmill test and by 84 ± 76% (P < 0.01) after the marathon run. There was no change in CD11b expression after the moderate 3-h run. CD18 expression was not significantly changed after any of the exercise protocols. Conclusion: Expression of CD11b on granulocytes is increased with intense endurance exercise, either incremental maximal treadmill testing or competitive marathon running, but not in moderate endurance training. Thus, exhaustive exercise may be one mechanism for the upregulation of integrin adhesive receptors on granulocytes. This phenomenon could be in part responsible for increased adhesion of granulocytes to endothelial cells and could facilitate tissue infiltration after endurance exercise." @default.
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• W2032025523 date "1999-03-01" @default.
• W2032025523 modified "2023-10-12" @default.
• W2032025523 title "Regulation of MAC-1 (CD11b/CD18) expression on circulating granulocytes in endurance runners" @default.
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• W2032025523 doi "https://doi.org/10.1097/00005768-199903000-00002" @default.
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