FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032031347> ?p ?o ?g. }

• W2032031347 endingPage "380" @default.
• W2032031347 startingPage "371" @default.
• W2032031347 abstract "Stem cell factor (SCF), the ligand for the c-kit receptor, is essential for the production of red blood cells during development and stress erythropoiesis. SCF promotes erythroblast proliferation and survival, while delaying erythroid differentiation through mechanisms that are largely unknown. In cultures of primary human differentiating erythroblasts, we found that SCF induces an increase in the expression of Notch2, a member of the Notch family implicated in the control of cell growth and differentiation. Functional inhibition of either Notch or its ligand Jagged1 inhibited the effects of SCF on erythroid cell expansion. SCF also induced the expression of Hes-1 and GATA-2, which may contribute to transduce Notch2 signals in response to SCF. Transduction of primary erythroid precursors with a dominant-negative Notch2 mutant inhibited both basal and SCF-mediated erythroblast expansion, and counteracted the effects of SCF on erythroblast differentiation. These findings provide a clue to understand the effects of increased proliferation and delayed differentiation elicited by SCF on the erythroid compartment and indicate Notch2 as a new player in the regulation of red cell differentiation." @default.
• W2032031347 created "2016-06-24" @default.
• W2032031347 creator A5003679742 @default.
• W2032031347 creator A5017459750 @default.
• W2032031347 creator A5030335157 @default.
• W2032031347 creator A5042097944 @default.
• W2032031347 creator A5045094013 @default.
• W2032031347 creator A5056876011 @default.
• W2032031347 creator A5057174985 @default.
• W2032031347 creator A5080731572 @default.
• W2032031347 creator A5087254707 @default.
• W2032031347 date "2010-09-10" @default.
• W2032031347 modified "2023-10-10" @default.
• W2032031347 title "The Notch2–Jagged1 interaction mediates stem cell factor signaling in erythropoiesis" @default.
• W2032031347 cites W1491665105 @default.
• W2032031347 cites W1911156364 @default.
• W2032031347 cites W1981074229 @default.
• W2032031347 cites W1987450508 @default.
• W2032031347 cites W1988382968 @default.
• W2032031347 cites W1990045619 @default.
• W2032031347 cites W1992183764 @default.
• W2032031347 cites W1994576664 @default.
• W2032031347 cites W1995383909 @default.
• W2032031347 cites W1997801717 @default.
• W2032031347 cites W1998662278 @default.
• W2032031347 cites W2003988449 @default.
• W2032031347 cites W2016034318 @default.
• W2032031347 cites W2017625115 @default.
• W2032031347 cites W2019250054 @default.
• W2032031347 cites W2037695813 @default.
• W2032031347 cites W2041952792 @default.
• W2032031347 cites W2054574471 @default.
• W2032031347 cites W2063436204 @default.
• W2032031347 cites W2067131315 @default.
• W2032031347 cites W2069441085 @default.
• W2032031347 cites W2075904779 @default.
• W2032031347 cites W2078113259 @default.
• W2032031347 cites W2079822259 @default.
• W2032031347 cites W2088257765 @default.
• W2032031347 cites W2097673163 @default.
• W2032031347 cites W2112811492 @default.
• W2032031347 cites W2118903548 @default.
• W2032031347 cites W2133943800 @default.
• W2032031347 cites W2140922568 @default.
• W2032031347 cites W2143096378 @default.
• W2032031347 cites W2160082285 @default.
• W2032031347 cites W2171623512 @default.
• W2032031347 cites W2258936525 @default.
• W2032031347 cites W341630348 @default.
• W2032031347 cites W82909710 @default.
• W2032031347 doi "https://doi.org/10.1038/cdd.2010.110" @default.
• W2032031347 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3131890" @default.
• W2032031347 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20829885" @default.
• W2032031347 hasPublicationYear "2010" @default.
• W2032031347 type Work @default.
• W2032031347 sameAs 2032031347 @default.
• W2032031347 citedByCount "22" @default.
• W2032031347 countsByYear W20320313472012 @default.
• W2032031347 countsByYear W20320313472013 @default.
• W2032031347 countsByYear W20320313472014 @default.
• W2032031347 countsByYear W20320313472015 @default.
• W2032031347 countsByYear W20320313472016 @default.
• W2032031347 countsByYear W20320313472018 @default.
• W2032031347 countsByYear W20320313472020 @default.
• W2032031347 countsByYear W20320313472021 @default.
• W2032031347 countsByYear W20320313472022 @default.
• W2032031347 crossrefType "journal-article" @default.
• W2032031347 hasAuthorship W2032031347A5003679742 @default.
• W2032031347 hasAuthorship W2032031347A5017459750 @default.
• W2032031347 hasAuthorship W2032031347A5030335157 @default.
• W2032031347 hasAuthorship W2032031347A5042097944 @default.
• W2032031347 hasAuthorship W2032031347A5045094013 @default.
• W2032031347 hasAuthorship W2032031347A5056876011 @default.
• W2032031347 hasAuthorship W2032031347A5057174985 @default.
• W2032031347 hasAuthorship W2032031347A5080731572 @default.
• W2032031347 hasAuthorship W2032031347A5087254707 @default.
• W2032031347 hasBestOaLocation W20320313471 @default.
• W2032031347 hasConcept C104317684 @default.
• W2032031347 hasConcept C109159458 @default.
• W2032031347 hasConcept C111368507 @default.
• W2032031347 hasConcept C126322002 @default.
• W2032031347 hasConcept C127313418 @default.
• W2032031347 hasConcept C148738053 @default.
• W2032031347 hasConcept C161879069 @default.
• W2032031347 hasConcept C185592680 @default.
• W2032031347 hasConcept C2022786 @default.
• W2032031347 hasConcept C203635412 @default.
• W2032031347 hasConcept C2778248108 @default.
• W2032031347 hasConcept C2779703530 @default.
• W2032031347 hasConcept C28328180 @default.
• W2032031347 hasConcept C2909030593 @default.
• W2032031347 hasConcept C54355233 @default.
• W2032031347 hasConcept C62478195 @default.
• W2032031347 hasConcept C71924100 @default.
• W2032031347 hasConcept C86803240 @default.
• W2032031347 hasConcept C95444343 @default.
• W2032031347 hasConceptScore W2032031347C104317684 @default.
• W2032031347 hasConceptScore W2032031347C109159458 @default.

• next