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- W2032033142 abstract "Prolonged, continuous exposure of the islets of Langerhans to highglucose concentrations results in desensitization of the beta cell to glucosestimulation. This study tested the ability of a sulphonylurea to stimulate insulinsecretion in this setting. Normal isolated rat islets were cultured for 18–20 h inRPMI-1640 with 300 mg/dl glucose to induce desensitization or with 100 mg/dl as a control. Islets were then placed into a perifusion system and perifused with 60 mg/dl glucose followed by a stimulus. After preincubation at 300 mg/dl, asignificant 50% suppression of glucose-induced insulin secretion compared with secretion in the control group preincubated at 100 mg/dl glucose was observed (p < 0.025–0.001). This confirmed the occurrence of desensitizationto glucose in this in vitro model. In contrast, stimulation of insulin secretion by glyburide (500 ng/ml) was unaffected compared with control. We also tested whether glyburide corrects the defective response to glucose stimulation inglucose-desensitized islets. Control islets (preincubated at 100 mg/dl) were stimulated with 300 mg/dl glucose or with this glucose concentration plus glyburide. Peak incremental insulin responses were similar (0.81 ± 0.07 and 0.77± 0.12 μU/ml.islet). After preincubation at 300 mg/dl, perifusion with 300mg/dl glucose alone or with glyburide was associated with smaller, but similar, peak insulin responses (0.53 ± 0.13 and 0.62 ± 0.06 μU/ml.islet). In conclusion, islets in which the insulin-secretory response is compromised by desensitization to glucose are nevertheless completely responsive to the direct stimulatory effects of a sulphonylurea. However, the sulphonylurea does not correct the defect in glucose-induced insulin secretion." @default.
- W2032033142 created "2016-06-24" @default.
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- W2032033142 date "1990-09-01" @default.
- W2032033142 modified "2023-09-26" @default.
- W2032033142 title "Sulphonylurea Effects on Insulin Secretion in Islets Desensitized to Glucose" @default.
- W2032033142 doi "https://doi.org/10.1097/00006676-199009000-00006" @default.
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