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- W2032034914 abstract "In mammalian eggs, sperm-induced Ca2+ oscillations at fertilization are the primary trigger for egg activation and initiation of embryonic development. Identifying the downstream effectors that decode this unique Ca2+ signal is essential to understand how the transition from egg to embryo is coordinated. Here, we investigated whether conventional PKCs (cPKCs) can decode Ca2+ oscillations at fertilization. By monitoring the dynamics of GFP-labeled PKCα and PKCγ in living mouse eggs, we demonstrate that cPKCs translocate to the egg membrane at fertilization following a pattern that is shaped by the amplitude, duration, and frequency of the Ca2+ transients. In addition, we show that cPKC translocation is driven by the C2 domain when Ca2+ concentration reaches 1–3 μM. Finally, we present evidence that one physiological function of activated cPKCs in fertilized eggs is to sustain long-lasting Ca2+ oscillations, presumably via the regulation of store-operated Ca2+ entry." @default.
- W2032034914 created "2016-06-24" @default.
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- W2032034914 date "2004-03-29" @default.
- W2032034914 modified "2023-10-16" @default.
- W2032034914 title "Conventional PKCs regulate the temporal pattern of Ca2+ oscillations at fertilization in mouse eggs" @default.
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- W2032034914 doi "https://doi.org/10.1083/jcb.200311023" @default.
- W2032034914 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2172066" @default.
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