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- W2032035538 abstract "Adult CBA mice injected with Moloney Sarcoma Virus (MSV) developed tumors within 5 to 8 days which usually completely regressed within 1 month. Maximal tumor size was variable, occurring between 10 and 15 days. Lymphocytes from these animals were examined for activity against syngeneic target cells bearing the Moloney Leukemia Virus (MLV) -associate dcell-surface antigen. As previously found with BALB/c mice, the lymphocytes were found to be active in microcytotoxicity tests against these target cells; however, the animals which were bearing tumors at the time of testing were found to have the least active lymphocytes. These animals were also immunized against H-2d antigens 10 to 13 days prior to testing and their lymphocytes tested for cytotoxicity against H-2d target cells in 51Cr release assays. It was found that the tumor-bearing animals, by day 10-16 after MSV infection, had lymphocytes which were significantly less active against the H-2d antigens than those of animals tested prior to the development of tumor or those in which the tumors had regressed. It was thus concluded that a component of the cellular hyporeactivity, as measured by in vitro cytotoxicity in these primary MSV tumor bearing hosts, is non-specific." @default.
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- W2032035538 date "1974-11-15" @default.
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- W2032035538 title "The lymphocyte response to primary moloney sarcoma virus tumors: Definition of a non-specific component of thein vitro cellular hyporeactivity of tumor-bearing hosts" @default.
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- W2032035538 doi "https://doi.org/10.1002/ijc.2910140511" @default.
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