FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032036629> ?p ?o ?g. }

• W2032036629 endingPage "549" @default.
• W2032036629 startingPage "545" @default.
• W2032036629 abstract "Abstract Sucrase-isomaltase (SI) is a highly N- and O-glycosylated intestinal brush border membrane protein. SI is sorted with high fidelity to the apical membrane via O-linked glycans that mediate its association with lipid rafts or detergent-resistant membranes (DRMs). Here, we show that N- and O-glycosylation and DRMs are implicated in the regulation of the function of SI in intestinal Caco-2 cells. The activities of sucrase (SUC) and isomaltase (IM) increase substantially in DRMs when N- and O-glycosylation patterns are intact. Disruption of DRMs by solubilization with Triton X-100 at 37°C substantially reduces the activities of SUC and IM. Furthermore, modulation of O-glycosylation by benzyl-2-acetamido-2-deoxy-α- d -galactopyranoside and N-glycosylation by deoxymannojirimycin is linked to a decreased capacity of SI to associate with DRMs, with a subsequent reduction of the enzymatic activities of SUC and IM. This is the first report that reveals a direct role of N- and O-glycans in association with DRMs in regulating the function of a membrane glycoprotein." @default.
• W2032036629 created "2016-06-24" @default.
• W2032036629 creator A5021354737 @default.
• W2032036629 creator A5044873395 @default.
• W2032036629 creator A5071929739 @default.
• W2032036629 creator A5075710974 @default.
• W2032036629 date "2009-05-09" @default.
• W2032036629 modified "2023-09-25" @default.
• W2032036629 title "Impact of glycosylation and detergent-resistant membranes on the function of intestinal sucrase-isomaltase" @default.
• W2032036629 cites W1538933232 @default.
• W2032036629 cites W1548179157 @default.
• W2032036629 cites W1586096959 @default.
• W2032036629 cites W1651616001 @default.
• W2032036629 cites W1670186976 @default.
• W2032036629 cites W1672352349 @default.
• W2032036629 cites W1726708958 @default.
• W2032036629 cites W1964117622 @default.
• W2032036629 cites W1966110715 @default.
• W2032036629 cites W1966551225 @default.
• W2032036629 cites W1975073093 @default.
• W2032036629 cites W1986385611 @default.
• W2032036629 cites W1993109473 @default.
• W2032036629 cites W1996394361 @default.
• W2032036629 cites W2052965907 @default.
• W2032036629 cites W2059939486 @default.
• W2032036629 cites W2064507821 @default.
• W2032036629 cites W2066719256 @default.
• W2032036629 cites W2071395559 @default.
• W2032036629 cites W2077218147 @default.
• W2032036629 cites W2086790785 @default.
• W2032036629 cites W2093289264 @default.
• W2032036629 cites W2096356941 @default.
• W2032036629 cites W2097598566 @default.
• W2032036629 cites W2100837269 @default.
• W2032036629 cites W2129232972 @default.
• W2032036629 cites W2399689694 @default.
• W2032036629 cites W2409615165 @default.
• W2032036629 cites W4293247451 @default.
• W2032036629 doi "https://doi.org/10.1515/bc.2009.077" @default.
• W2032036629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19426137" @default.
• W2032036629 hasPublicationYear "2009" @default.
• W2032036629 type Work @default.
• W2032036629 sameAs 2032036629 @default.
• W2032036629 citedByCount "26" @default.
• W2032036629 countsByYear W20320366292012 @default.
• W2032036629 countsByYear W20320366292013 @default.
• W2032036629 countsByYear W20320366292014 @default.
• W2032036629 countsByYear W20320366292015 @default.
• W2032036629 countsByYear W20320366292016 @default.
• W2032036629 countsByYear W20320366292017 @default.
• W2032036629 countsByYear W20320366292018 @default.
• W2032036629 countsByYear W20320366292019 @default.
• W2032036629 countsByYear W20320366292020 @default.
• W2032036629 countsByYear W20320366292021 @default.
• W2032036629 countsByYear W20320366292023 @default.
• W2032036629 crossrefType "journal-article" @default.
• W2032036629 hasAuthorship W2032036629A5021354737 @default.
• W2032036629 hasAuthorship W2032036629A5044873395 @default.
• W2032036629 hasAuthorship W2032036629A5071929739 @default.
• W2032036629 hasAuthorship W2032036629A5075710974 @default.
• W2032036629 hasConcept C108625454 @default.
• W2032036629 hasConcept C127413603 @default.
• W2032036629 hasConcept C130316041 @default.
• W2032036629 hasConcept C14036430 @default.
• W2032036629 hasConcept C144647389 @default.
• W2032036629 hasConcept C181199279 @default.
• W2032036629 hasConcept C185592680 @default.
• W2032036629 hasConcept C199639397 @default.
• W2032036629 hasConcept C206212055 @default.
• W2032036629 hasConcept C2776039999 @default.
• W2032036629 hasConcept C2777313579 @default.
• W2032036629 hasConcept C2777459641 @default.
• W2032036629 hasConcept C2779104521 @default.
• W2032036629 hasConcept C3019659684 @default.
• W2032036629 hasConcept C30324644 @default.
• W2032036629 hasConcept C41625074 @default.
• W2032036629 hasConcept C5426402 @default.
• W2032036629 hasConcept C55493867 @default.
• W2032036629 hasConcept C79266657 @default.
• W2032036629 hasConcept C86803240 @default.
• W2032036629 hasConcept C95444343 @default.
• W2032036629 hasConceptScore W2032036629C108625454 @default.
• W2032036629 hasConceptScore W2032036629C127413603 @default.
• W2032036629 hasConceptScore W2032036629C130316041 @default.
• W2032036629 hasConceptScore W2032036629C14036430 @default.
• W2032036629 hasConceptScore W2032036629C144647389 @default.
• W2032036629 hasConceptScore W2032036629C181199279 @default.
• W2032036629 hasConceptScore W2032036629C185592680 @default.
• W2032036629 hasConceptScore W2032036629C199639397 @default.
• W2032036629 hasConceptScore W2032036629C206212055 @default.
• W2032036629 hasConceptScore W2032036629C2776039999 @default.
• W2032036629 hasConceptScore W2032036629C2777313579 @default.
• W2032036629 hasConceptScore W2032036629C2777459641 @default.
• W2032036629 hasConceptScore W2032036629C2779104521 @default.
• W2032036629 hasConceptScore W2032036629C3019659684 @default.
• W2032036629 hasConceptScore W2032036629C30324644 @default.
• W2032036629 hasConceptScore W2032036629C41625074 @default.
• W2032036629 hasConceptScore W2032036629C5426402 @default.

• next