FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032037407> ?p ?o ?g. }

• W2032037407 endingPage "1361" @default.
• W2032037407 startingPage "1351" @default.
• W2032037407 abstract "Abstract We have recently demonstrated that the accumulation of labile zinc in lysosomes during oxidative stress causes lysosomal membrane permeabilization (LMP) in cultured hippocampal neurons. Since autophagy involves fusion of autophagic vacuoles (AVs) with lysosomes, zinc accumulation may start in AVs. In the present study, we examined the role of endogenous zinc in H 2 O 2 ‐induced autophagy and cell death in mouse astrocyte cultures. Live‐cell confocal imaging of astrocytes transfected with GFP‐LC3 revealed that the number of AVs positive for LC3 (microtubule‐associated protein 1 light chain 3) increased following exposure to H 2 O 2 or ferrous chloride (FeCl 2 ). Staining of RFP‐LC3‐transfected astrocytes with FluoZin‐3 indicated that the levels of labile zinc increased in AVs as well as in the cytosol and nuclei. The majority of AVs were double‐stained with LysoTracker, indicating that they were fused with lysosomes. Chelation of zinc with tetrakis [2‐pyridylmethyl]ethylenediamine (TPEN) decreased the number of AVs in H 2 O 2 ‐treated astrocytes, whereas exposure to zinc increased their number, suggesting that dysregulation of zinc homeostasis is mechanistically linked to autophagy. Unexpectedly, inhibition of autophagy blocked the rise in labile zinc levels. Astrocytic death induced by H 2 O 2 was accompanied by LMP. Autophagy inhibitors (3‐methyladenine, bafilomycin‐1) or TPEN attenuated LMP and cell death in astrocytes. These results support the possibility that endogenous zinc plays a key role in autophagy under oxidative stress in astrocytes, and suggest that autophagy is a necessary preceding event for LMP and cell death in oxidative injury. © 2009 Wiley‐Liss, Inc." @default.
• W2032037407 created "2016-06-24" @default.
• W2032037407 creator A5007409800 @default.
• W2032037407 creator A5045835004 @default.
• W2032037407 creator A5065337835 @default.
• W2032037407 date "2009-02-19" @default.
• W2032037407 modified "2023-10-16" @default.
• W2032037407 title "Oxidative injury triggers autophagy in astrocytes: The role of endogenous zinc" @default.
• W2032037407 cites W1521467205 @default.
• W2032037407 cites W1967111894 @default.
• W2032037407 cites W1990216374 @default.
• W2032037407 cites W1994823455 @default.
• W2032037407 cites W2006743483 @default.
• W2032037407 cites W2012122987 @default.
• W2032037407 cites W2022812113 @default.
• W2032037407 cites W2026688064 @default.
• W2032037407 cites W2032563727 @default.
• W2032037407 cites W2037100007 @default.
• W2032037407 cites W2052101545 @default.
• W2032037407 cites W2056367295 @default.
• W2032037407 cites W2061473417 @default.
• W2032037407 cites W2072007125 @default.
• W2032037407 cites W2072310161 @default.
• W2032037407 cites W2077440654 @default.
• W2032037407 cites W2082827967 @default.
• W2032037407 cites W2083521073 @default.
• W2032037407 cites W2085273994 @default.
• W2032037407 cites W2095386620 @default.
• W2032037407 cites W2106209450 @default.
• W2032037407 cites W2108225041 @default.
• W2032037407 cites W2108471384 @default.
• W2032037407 cites W2110090329 @default.
• W2032037407 cites W2123609069 @default.
• W2032037407 cites W2130287342 @default.
• W2032037407 cites W2145206598 @default.
• W2032037407 cites W2150983291 @default.
• W2032037407 cites W2157122489 @default.
• W2032037407 cites W2165126337 @default.
• W2032037407 cites W4293223175 @default.
• W2032037407 doi "https://doi.org/10.1002/glia.20854" @default.
• W2032037407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19229997" @default.
• W2032037407 hasPublicationYear "2009" @default.
• W2032037407 type Work @default.
• W2032037407 sameAs 2032037407 @default.
• W2032037407 citedByCount "103" @default.
• W2032037407 countsByYear W20320374072012 @default.
• W2032037407 countsByYear W20320374072013 @default.
• W2032037407 countsByYear W20320374072014 @default.
• W2032037407 countsByYear W20320374072015 @default.
• W2032037407 countsByYear W20320374072016 @default.
• W2032037407 countsByYear W20320374072017 @default.
• W2032037407 countsByYear W20320374072018 @default.
• W2032037407 countsByYear W20320374072019 @default.
• W2032037407 countsByYear W20320374072020 @default.
• W2032037407 countsByYear W20320374072021 @default.
• W2032037407 countsByYear W20320374072022 @default.
• W2032037407 countsByYear W20320374072023 @default.
• W2032037407 crossrefType "journal-article" @default.
• W2032037407 hasAuthorship W2032037407A5007409800 @default.
• W2032037407 hasAuthorship W2032037407A5045835004 @default.
• W2032037407 hasAuthorship W2032037407A5065337835 @default.
• W2032037407 hasConcept C102568950 @default.
• W2032037407 hasConcept C134018914 @default.
• W2032037407 hasConcept C16613235 @default.
• W2032037407 hasConcept C178790620 @default.
• W2032037407 hasConcept C181199279 @default.
• W2032037407 hasConcept C185592680 @default.
• W2032037407 hasConcept C190062978 @default.
• W2032037407 hasConcept C190283241 @default.
• W2032037407 hasConcept C203522944 @default.
• W2032037407 hasConcept C2776151105 @default.
• W2032037407 hasConcept C2777542381 @default.
• W2032037407 hasConcept C2777722557 @default.
• W2032037407 hasConcept C31573885 @default.
• W2032037407 hasConcept C529278444 @default.
• W2032037407 hasConcept C535196362 @default.
• W2032037407 hasConcept C55493867 @default.
• W2032037407 hasConcept C86803240 @default.
• W2032037407 hasConcept C95444343 @default.
• W2032037407 hasConcept C98539663 @default.
• W2032037407 hasConceptScore W2032037407C102568950 @default.
• W2032037407 hasConceptScore W2032037407C134018914 @default.
• W2032037407 hasConceptScore W2032037407C16613235 @default.
• W2032037407 hasConceptScore W2032037407C178790620 @default.
• W2032037407 hasConceptScore W2032037407C181199279 @default.
• W2032037407 hasConceptScore W2032037407C185592680 @default.
• W2032037407 hasConceptScore W2032037407C190062978 @default.
• W2032037407 hasConceptScore W2032037407C190283241 @default.
• W2032037407 hasConceptScore W2032037407C203522944 @default.
• W2032037407 hasConceptScore W2032037407C2776151105 @default.
• W2032037407 hasConceptScore W2032037407C2777542381 @default.
• W2032037407 hasConceptScore W2032037407C2777722557 @default.
• W2032037407 hasConceptScore W2032037407C31573885 @default.
• W2032037407 hasConceptScore W2032037407C529278444 @default.
• W2032037407 hasConceptScore W2032037407C535196362 @default.
• W2032037407 hasConceptScore W2032037407C55493867 @default.
• W2032037407 hasConceptScore W2032037407C86803240 @default.
• W2032037407 hasConceptScore W2032037407C95444343 @default.

• next