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• W2032040300 abstract "A water soluble β-d-glucan was isolated by 70% ethanol aqueous solution from Auricularia auricula-judae, coded as AAG. AAG exhibited strong inhibition against Acinar cell carcinoma (ACC) proliferation. The in vivo tests showed that AAG significantly inhibited tumor growth in a dose-dependent fashion, but not because of cytotoxicity. All the doses showed certain inhibition ratios against tumor-cell growth, while the dose of 20 mg/kg exhibited highest anti-tumor activities. Moreover, the enhancement ratios of body weight for all the doses were significantly higher than that for 5-fluorouracil (5-Fu). Fluorescence microscopy observed the apoptosis tumor cell induced by AGG sample. The results from TUNEL assay further confirmed the apoptosis in Sarcoma 180 solid tumor. Immunohistochemistry for apoptosis-related proteins Bax and Bcl-2 expression tests revealed that AAG induced S-180 tumor cell apoptosis by up-regulation of Bax and down-regulation of Bcl-2 expression. These findings demonstrated that the AAG has biological activities and could be considered as a candidate for possible anti-tumor drugs." @default.
• W2032040300 created "2016-06-24" @default.
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• W2032040300 date "2010-05-05" @default.
• W2032040300 modified "2023-09-30" @default.
• W2032040300 title "Evaluation of water soluble β-d-glucan from Auricularia auricular-judae as potential anti-tumor agent" @default.
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• W2032040300 doi "https://doi.org/10.1016/j.carbpol.2010.01.015" @default.
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