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• W2032047507 startingPage "4270" @default.
• W2032047507 abstract "Purpose.: The biomechanical effects of IOP on the optic nerve head (ONH) are believed to play a role in glaucomatous neuropathy. There is, however, no consensus on which effects of IOP should be prioritized for investigation. Our goal was to identify a small set of variables capturing the majority of the effects of acute IOP on the ONH. Methods.: We produced 4646 finite element models of the human ONH representing a wide range of tissue anatomies and mechanical properties. The effects of IOP were quantified through a set of 25 responses including stress, strain, and geometric deformation of the lamina cribrosa (LC) and peripapillary sclera. The correlations between the responses were analyzed and principal component analysis (PCA) was used to identify uncorrelated variables capturing the largest possible variance in the responses. Results.: The responses formed groups with strong correlations. The top five principal components (PCs) accounted for 72.8%, 13.0%, 7.1%, 3.1%, and 2.0% of the variance, respectively. Conclusions.: Few PCs capture the majority of the mechanical effects of acute changes in IOP on the ONH, which previously required 25 measures. The PCs represented four key effects of IOP: lateral deformation associated with canal expansion (PC1), anterior-posterior deformation of the LC and the forces through it determined by either the mechanical properties of the LC (PC2) or of the neural tissue (PC4), rotation of the peripapillary sclera (PC5), and forces through the peripapillary sclera (PC3). A small set of uncorrelated variables will simplify describing and understanding the effects of IOP on the ONH." @default.
• W2032047507 created "2016-06-24" @default.
• W2032047507 creator A5055790825 @default.
• W2032047507 creator A5076141055 @default.
• W2032047507 date "2012-06-28" @default.
• W2032047507 modified "2023-10-16" @default.
• W2032047507 title "A Few Good Responses: Which Mechanical Effects of IOP on the ONH to Study?" @default.
• W2032047507 cites W1489326049 @default.
• W2032047507 cites W1548802052 @default.
• W2032047507 cites W1553296127 @default.
• W2032047507 cites W1606655603 @default.
• W2032047507 cites W1902640952 @default.
• W2032047507 cites W1964210566 @default.
• W2032047507 cites W1967292313 @default.
• W2032047507 cites W1969106885 @default.
• W2032047507 cites W1970047175 @default.
• W2032047507 cites W1973743168 @default.
• W2032047507 cites W1978097677 @default.
• W2032047507 cites W1979009161 @default.
• W2032047507 cites W1979463746 @default.
• W2032047507 cites W1980011029 @default.
• W2032047507 cites W1980368328 @default.
• W2032047507 cites W1982537788 @default.
• W2032047507 cites W1982819517 @default.
• W2032047507 cites W1985842635 @default.
• W2032047507 cites W1991821214 @default.
• W2032047507 cites W1993367864 @default.
• W2032047507 cites W1994652894 @default.
• W2032047507 cites W1995747752 @default.
• W2032047507 cites W2000753532 @default.
• W2032047507 cites W2009404629 @default.
• W2032047507 cites W2009930015 @default.
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• W2032047507 cites W2022352073 @default.
• W2032047507 cites W2022805799 @default.
• W2032047507 cites W2031770605 @default.
• W2032047507 cites W2036246166 @default.
• W2032047507 cites W2043817890 @default.
• W2032047507 cites W2047268748 @default.
• W2032047507 cites W2051328650 @default.
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• W2032047507 cites W2067678530 @default.
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• W2032047507 cites W2076386520 @default.
• W2032047507 cites W2078332202 @default.
• W2032047507 cites W2078704266 @default.
• W2032047507 cites W2080423156 @default.
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• W2032047507 cites W2146186219 @default.
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• W2032047507 doi "https://doi.org/10.1167/iovs.11-8739" @default.
• W2032047507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3392011" @default.
• W2032047507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22570343" @default.
• W2032047507 hasPublicationYear "2012" @default.
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