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• W2032051482 abstract "Vitamin D is essential for bone mineralization and for the subsequent maintenance of bone quality. Mineralization is part of hard callus formation and bone remodelling, processes, which are part of fracture healing. We provide a comprehensive review of the literature to summarize and clarify if possible, the cellular effects of vitamin D and its clinical involvement in the process of fracture healing in human. We conducted a literature search in PubMed, Embase (OVID version), and Web of Science. A total of 75 in vitro and 30 in vivo studies were found with inconsistent results about the cellular effect of vitamin D on fracture involved inflammatory cells, cytokines, growth factors, osteoblasts, osteoclasts and on the process of mineralization. With only five in vitro studies performed on material derived from a fracture site and one in vivo study in fracture patients, the exact cellular role remains unclear. Seven studies investigated the circulating vitamin D metabolites in fracture healing. Although it appears that 25(OH)D and 24,25(OH)2D3 are not affected by the occurrence of a fracture, this might not be the case with serum concentrations of 1,25(OH)2D3. The potential clinical effect of vitamin D deficiency is only described in one case series and three case controlled studies, where the results tend to show no effect of a vitamin D deficiency. No clinical studies were found investigating solely vitamin D supplementation. Two clinical studies found a positive effect of vitamin D supplementation and calcium, of increased bone mineral density or respectively increased fracture callus area at the fracture site. One study found indirect evidence that vitamin D and calcium promoted fracture healing. Despite these results, and the presumed beneficial effect of vitamin D supplementation in deficient patients, clinical studies that address the effects of vitamin D deficiency or supplementation on fracture healing are scarce and remain inconclusive. We conclude that vitamin D has a role in fracture healing, but the available data are too inconsistent to elucidate how and in what manner." @default.
• W2032051482 created "2016-06-24" @default.
• W2032051482 creator A5006614192 @default.
• W2032051482 creator A5050756496 @default.
• W2032051482 creator A5080314023 @default.
• W2032051482 creator A5091368864 @default.
• W2032051482 date "2014-07-01" @default.
• W2032051482 modified "2023-10-01" @default.
• W2032051482 title "The role of vitamin D in human fracture healing: a systematic review of the literature" @default.
• W2032051482 cites W1506557546 @default.
• W2032051482 cites W1579748293 @default.
• W2032051482 cites W1964479969 @default.
• W2032051482 cites W1969900093 @default.
• W2032051482 cites W1973291424 @default.
• W2032051482 cites W1973762194 @default.
• W2032051482 cites W1974868540 @default.
• W2032051482 cites W1980980469 @default.
• W2032051482 cites W1982400943 @default.
• W2032051482 cites W1984833486 @default.
• W2032051482 cites W1987598132 @default.
• W2032051482 cites W1988314386 @default.
• W2032051482 cites W1991632481 @default.
• W2032051482 cites W1994560008 @default.
• W2032051482 cites W1995575762 @default.
• W2032051482 cites W1996116098 @default.
• W2032051482 cites W1996480023 @default.
• W2032051482 cites W1997434076 @default.
• W2032051482 cites W1997581290 @default.
• W2032051482 cites W1997981318 @default.
• W2032051482 cites W2001313880 @default.
• W2032051482 cites W2002722270 @default.
• W2032051482 cites W2003116535 @default.
• W2032051482 cites W2005167663 @default.
• W2032051482 cites W2011630862 @default.
• W2032051482 cites W2013089096 @default.
• W2032051482 cites W2014114648 @default.
• W2032051482 cites W2014143435 @default.
• W2032051482 cites W2015909736 @default.
• W2032051482 cites W2016210371 @default.
• W2032051482 cites W2017547192 @default.
• W2032051482 cites W2017851530 @default.
• W2032051482 cites W2019113771 @default.
• W2032051482 cites W2020874304 @default.
• W2032051482 cites W2021409342 @default.
• W2032051482 cites W2022388321 @default.
• W2032051482 cites W2022673315 @default.
• W2032051482 cites W2023845557 @default.
• W2032051482 cites W2025669404 @default.
• W2032051482 cites W2029057822 @default.
• W2032051482 cites W2030709706 @default.
• W2032051482 cites W2031442218 @default.
• W2032051482 cites W2032763597 @default.
• W2032051482 cites W2033269136 @default.
• W2032051482 cites W2033966283 @default.
• W2032051482 cites W2034862169 @default.
• W2032051482 cites W2036557984 @default.
• W2032051482 cites W2038249140 @default.
• W2032051482 cites W2038728707 @default.
• W2032051482 cites W2042037577 @default.
• W2032051482 cites W2042441922 @default.
• W2032051482 cites W2042887349 @default.
• W2032051482 cites W2046214413 @default.
• W2032051482 cites W2046932891 @default.
• W2032051482 cites W2049426433 @default.
• W2032051482 cites W2051294232 @default.
• W2032051482 cites W2051844469 @default.
• W2032051482 cites W2054391164 @default.
• W2032051482 cites W2054630945 @default.
• W2032051482 cites W2060038073 @default.
• W2032051482 cites W2061528612 @default.
• W2032051482 cites W2062076773 @default.
• W2032051482 cites W2062159615 @default.
• W2032051482 cites W2066417441 @default.
• W2032051482 cites W2070167568 @default.
• W2032051482 cites W2071433608 @default.
• W2032051482 cites W2072100512 @default.
• W2032051482 cites W2072480224 @default.
• W2032051482 cites W2073261329 @default.
• W2032051482 cites W2078575409 @default.
• W2032051482 cites W2080167340 @default.
• W2032051482 cites W2081047941 @default.
• W2032051482 cites W2082668830 @default.
• W2032051482 cites W2082846795 @default.
• W2032051482 cites W2082888013 @default.
• W2032051482 cites W2083776658 @default.
• W2032051482 cites W2084385231 @default.
• W2032051482 cites W2085747557 @default.
• W2032051482 cites W2086296065 @default.
• W2032051482 cites W2092804172 @default.
• W2032051482 cites W2093622873 @default.
• W2032051482 cites W2094540519 @default.
• W2032051482 cites W2094911676 @default.
• W2032051482 cites W2096282084 @default.
• W2032051482 cites W2099551278 @default.
• W2032051482 cites W2099754137 @default.
• W2032051482 cites W2101678293 @default.
• W2032051482 cites W2105304450 @default.
• W2032051482 cites W2106647095 @default.

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