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- W2032052263 endingPage "72" @default.
- W2032052263 startingPage "65" @default.
- W2032052263 abstract "High frequency of chromosomal deletions elicited as losses of heterozygosity is a hallmark of genomic instability in cancer. Functional losses of tumor suppressor genes caused by loss of heterozygosity at defined regions during clonal selection for growth advantage define the minimally lost regions as their likely locations on chromosomes. Loss of heterozygosity is elicited at the molecular or cytogenetic level as a deletion, a gene conversion, single or double homologous and nonhomologous mitotic recombinations, a translocation, chromosome breakage and loss, chromosomal fusion or telomeric end-to-end fusions, or whole chromosome loss with or without accompanying duplication of the retained chromosome. Because of the high level of specificity, loss of heterozygosity has recently become invaluable as a marker for diagnosis and prognosis of cancer. The molecular defects for the occurrence of loss of heterozygosity are derived from disabled caretaker genes, which protect the integrity of DNA, or chromosome segregator genes, which mediate faithful chromosome disjunction." @default.
- W2032052263 created "2016-06-24" @default.
- W2032052263 creator A5006536958 @default.
- W2032052263 creator A5017059976 @default.
- W2032052263 creator A5027803351 @default.
- W2032052263 creator A5045542232 @default.
- W2032052263 creator A5045793555 @default.
- W2032052263 creator A5072757774 @default.
- W2032052263 date "2002-01-01" @default.
- W2032052263 modified "2023-09-30" @default.
- W2032052263 title "Loss of heterozygosity as a predictor to map tumor suppressor genes in cancer: molecular basis of its occurrence" @default.
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