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- W2032053824 abstract "Phosphorus-31 nuclear magnetic resonance spectroscopy has been recently increasingly used to study cellular metabolism in a manner respecting the cell integrity. Intrinsic advantages of the phosphorus nucleus for in vivo NMR studies are discussed in this review together with some selected applications. A particular emphasis is layed on metabolite identification and quantitation (relative and absolute concentrations), the measurement of intracellular pH and the problem of cellular compartmentation. The determination of metabolite fluxes under normal and abnormal biological and physiological conditions, and the in vivo direct measurement by saturation transfer techniques of kinetic parameters for enzymatic reactions at equilibrium, are illustrated by several examples taken from the available literature and work carried out in this laboratory. Whenever possible, and appropriate, the NMR approach has been compared with other more classical techniques of investigation. The future and the potentialities of phosphorus-31 NMR study of intact biological systems, the clinical applications and the foreseeable interfacing with imaging techniques are evaluated. The concept of functional imaging versus anatomic imaging is proposed to illustrate the impact of this new technology in the understanding of cellular mechanisms, not only in the intact cell but also in whole tissues or organs after excision or in living animals and human." @default.
- W2032053824 created "2016-06-24" @default.
- W2032053824 creator A5014053958 @default.
- W2032053824 creator A5075500529 @default.
- W2032053824 creator A5085978408 @default.
- W2032053824 date "1983-10-01" @default.
- W2032053824 modified "2023-09-25" @default.
- W2032053824 title "Étude du métabolisme cellulaire in vivo par résonance magnétique nucléaire du phosphore-31" @default.
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- W2032053824 doi "https://doi.org/10.1016/s0300-9084(83)80127-8" @default.