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- W2032053892 abstract "Exposure to oxygen during the neonatal period is fraught with deleterious effects on lung growth and morphology(Ped Pulm 1993;16:81). Investigators have shown reduced body weight in various species subjected to oxygen exposure. The purpose of this investigation was to evaluate the effects of Hyperoxia (85% FiO2) on somaticovisceral growth in mice. Mice were bred and their offspring were randomized at 2 days of age to receive 85%FiO2(O2) or room air (RA) under controlled temperature, humidity barometric pressure and diurnal cycles Mothers were exposed to oxygen for no longer than 24 hours and alternated to minimize oxygen toxicity. The mice were offered mice chow and water ad lib. Both RA and O2 exposed mice received equivalent nutrient intake. Each group was exposed to 7, 15, or 30days of experimental or control conditions. We measured body weight, and wet to dry weights of selected organs. Data for 30 days exposure is expressed as X± (SD) (mg) Table There were significant differences in final bodyweight between O2 exposed and RA (11.08(1.2) vs 17.2(0.87)gms)p< 0.001 at 30 days. Hyperoxia exposure affected organ growth of heart, lung and brain as early as 7 days of exposure while the most pronounced effect on all organs studied occurred at 30 days. At 30 days heart, lungs, liver and spleen had significant differences in wet/dry ratios suggestive of edema. We conclude that hyperoxia adversely affects somaticovisceral growth. Whether these differences in organ growth are related to impaired protein synthesis and /or impaired growth factors remains to be elucidated." @default.
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- W2032053892 date "1996-04-01" @default.
- W2032053892 modified "2023-09-25" @default.
- W2032053892 title "Hyperoxia Affects Somaticovisceral Growth. 363" @default.
- W2032053892 doi "https://doi.org/10.1203/00006450-199604001-00383" @default.
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