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- W2032054654 abstract "<h3>Background</h3> Concern has been raised that high levels of ascorbic acid consumption may lead to potential adverse effects, such as vitamin B<sub>12</sub>deficiency, iron overload, and kidney stones. <h3>Objective</h3> To examine the relation of serum ascorbic acid level, which reflects intake, to serum vitamin B<sub>12</sub>level, serum ferritin level, and kidney stones. <h3>Methods</h3> We analyzed data collected on a random sample of the US population enrolled in the Second National Health and Nutrition Examination Survey, 1976-1980. We analyzed data using linear and logistic regression models. Serum ascorbic acid, serum vitamin B<sub>12</sub>, hemoglobin, red blood cell mean corpuscular volume (MCV), and serum ferritin levels were measured using standardized protocols. History of kidney stones was determined by self-report. <h3>Results</h3> After multivariate adjustment, serum ascorbic acid level was associated with higher serum vitamin B<sub>12</sub>levels among women in regression models that assumed a linear relationship; each 57-µmol/L (1.0-mg/dL) increase in serum ascorbic acid level (range, 6-153 µmol/L [0.1 to 2.7 mg/dL]) was independently associated with a serum vitamin B<sub>12</sub>level increase of 60 pmol/L (81 pg/mL) (<i>P</i><.001). Among men, serum ascorbic acid level was marginally associated with higher serum vitamin B<sub>12</sub>levels: each 57-µmol/L (1.0-mg/dL) increase in serum ascorbic acid level was associated with a serum vitamin B<sub>12</sub>level increase of 27 pmol/L (36 pg/mL) (<i>P</i>=.10). In addition, serum ascorbic acid level was not associated with correlates of vitamin B<sub>12</sub>deficiency, such as higher MCV levels, macrocytosis (MCV >100), or lower hemoglobin concentrations. Serum ascorbic acid level was not independently associated with serum ferritin levels. However, among women only, serum ascorbic acid levels were associated in a nonlinear fashion with prevalence of elevated serum ferritin levels (<i>P</i>=.02). We found no association between serum ascorbic acid level and prevalence of kidney stones in women or men (both<i>P</i>>.05). <h3>Conclusions</h3> Serum ascorbic acid levels were not associated with decreased serum vitamin B<sub>12</sub>levels (or indicators of vitamin B<sub>12</sub>deficiency), prevalence of kidney stones, serum ferritin levels, or—among men—prevalence of elevated serum ferritin levels. Serum ascorbic acid levels were associated with prevalence of elevated serum ferritin levels among women. Although the clinical relevance of these findings is uncertain, it seems prudent to suggest that women with a genetic susceptibility to iron overload should consider moderating their intake of ascorbic acid." @default.
- W2032054654 created "2016-06-24" @default.
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- W2032054654 date "1999-03-22" @default.
- W2032054654 modified "2023-10-10" @default.
- W2032054654 title "Relation of Serum Ascorbic Acid to Serum Vitamin B12, Serum Ferritin, and Kidney Stones in US Adults" @default.
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- W2032054654 doi "https://doi.org/10.1001/archinte.159.6.619" @default.
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