Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032056336> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2032056336 endingPage "203" @default.
- W2032056336 startingPage "193" @default.
- W2032056336 abstract "Low-molecular weight heparins (LMWHs), as compared with unfractionated heparin (UFH), present superior bioavailability, much longer plasma half-life, and lower incidence of side effects. For these reasons, over the past two decades LMWHs have become the drugs of choice for the treatment of deep venous thrombosis, pulmonary embolism, arterial thrombosis, and unstable angina. Furthermore, their use in acute ischemic stroke is currently under study. LMWHs are obtained by UFH depolymerization, which can be performed using various methods, including nitrous acid depolymerization, cleavage by beta-elimination of benzyl ester, enzymatic depolymerization, and peroxyl radical-dependent depolymerization. This article addresses the chemical depolymerization, obtained by free radical attack (mainly hydroxyl radical), of heparin. The electron spin resonance (ESR) spectroscopy, coupled to the spin trapping technique, was employed to study this reaction. Free radical-mediated heparin depolymerization was performed under different chemical conditions. The final products of the reactions were purified and classified on the basis of their molecular weight and other characteristics. The level of heparin fragmentation was different depending on the type of depolymerization reaction used. Moreover, the level of reproducibility and the resulting radical species were different for every type of reaction performed." @default.
- W2032056336 created "2016-06-24" @default.
- W2032056336 creator A5015465170 @default.
- W2032056336 creator A5028640520 @default.
- W2032056336 creator A5032173189 @default.
- W2032056336 creator A5060308256 @default.
- W2032056336 creator A5071179624 @default.
- W2032056336 creator A5082676214 @default.
- W2032056336 creator A5091682661 @default.
- W2032056336 date "2005-09-01" @default.
- W2032056336 modified "2023-10-05" @default.
- W2032056336 title "Free radical generation during chemical depolymerization of heparin" @default.
- W2032056336 cites W1502638249 @default.
- W2032056336 cites W1574893341 @default.
- W2032056336 cites W1964500091 @default.
- W2032056336 cites W1968468292 @default.
- W2032056336 cites W1988054144 @default.
- W2032056336 cites W2020128873 @default.
- W2032056336 cites W2021764672 @default.
- W2032056336 cites W2028222320 @default.
- W2032056336 cites W2037941352 @default.
- W2032056336 cites W2041240824 @default.
- W2032056336 cites W2041859957 @default.
- W2032056336 cites W2056603482 @default.
- W2032056336 cites W2058727554 @default.
- W2032056336 cites W2060026323 @default.
- W2032056336 cites W2063207586 @default.
- W2032056336 cites W2064803590 @default.
- W2032056336 cites W2085215055 @default.
- W2032056336 cites W2093000016 @default.
- W2032056336 cites W2110285942 @default.
- W2032056336 cites W2077037924 @default.
- W2032056336 doi "https://doi.org/10.1016/j.ab.2005.06.043" @default.
- W2032056336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16098471" @default.
- W2032056336 hasPublicationYear "2005" @default.
- W2032056336 type Work @default.
- W2032056336 sameAs 2032056336 @default.
- W2032056336 citedByCount "22" @default.
- W2032056336 countsByYear W20320563362012 @default.
- W2032056336 countsByYear W20320563362015 @default.
- W2032056336 countsByYear W20320563362016 @default.
- W2032056336 countsByYear W20320563362017 @default.
- W2032056336 countsByYear W20320563362018 @default.
- W2032056336 countsByYear W20320563362020 @default.
- W2032056336 countsByYear W20320563362021 @default.
- W2032056336 countsByYear W20320563362022 @default.
- W2032056336 countsByYear W20320563362023 @default.
- W2032056336 crossrefType "journal-article" @default.
- W2032056336 hasAuthorship W2032056336A5015465170 @default.
- W2032056336 hasAuthorship W2032056336A5028640520 @default.
- W2032056336 hasAuthorship W2032056336A5032173189 @default.
- W2032056336 hasAuthorship W2032056336A5060308256 @default.
- W2032056336 hasAuthorship W2032056336A5071179624 @default.
- W2032056336 hasAuthorship W2032056336A5082676214 @default.
- W2032056336 hasAuthorship W2032056336A5091682661 @default.
- W2032056336 hasConcept C111919701 @default.
- W2032056336 hasConcept C139066938 @default.
- W2032056336 hasConcept C178790620 @default.
- W2032056336 hasConcept C185592680 @default.
- W2032056336 hasConcept C191015642 @default.
- W2032056336 hasConcept C2777557582 @default.
- W2032056336 hasConcept C41008148 @default.
- W2032056336 hasConcept C49852136 @default.
- W2032056336 hasConcept C55493867 @default.
- W2032056336 hasConceptScore W2032056336C111919701 @default.
- W2032056336 hasConceptScore W2032056336C139066938 @default.
- W2032056336 hasConceptScore W2032056336C178790620 @default.
- W2032056336 hasConceptScore W2032056336C185592680 @default.
- W2032056336 hasConceptScore W2032056336C191015642 @default.
- W2032056336 hasConceptScore W2032056336C2777557582 @default.
- W2032056336 hasConceptScore W2032056336C41008148 @default.
- W2032056336 hasConceptScore W2032056336C49852136 @default.
- W2032056336 hasConceptScore W2032056336C55493867 @default.
- W2032056336 hasIssue "2" @default.
- W2032056336 hasLocation W20320563361 @default.
- W2032056336 hasLocation W20320563362 @default.
- W2032056336 hasOpenAccess W2032056336 @default.
- W2032056336 hasPrimaryLocation W20320563361 @default.
- W2032056336 hasRelatedWork W1992248793 @default.
- W2032056336 hasRelatedWork W2008644872 @default.
- W2032056336 hasRelatedWork W2084186860 @default.
- W2032056336 hasRelatedWork W2164471494 @default.
- W2032056336 hasRelatedWork W2332828526 @default.
- W2032056336 hasRelatedWork W2950543049 @default.
- W2032056336 hasRelatedWork W2952237413 @default.
- W2032056336 hasRelatedWork W2953023711 @default.
- W2032056336 hasRelatedWork W1963652940 @default.
- W2032056336 hasRelatedWork W1967438604 @default.
- W2032056336 hasVolume "344" @default.
- W2032056336 isParatext "false" @default.
- W2032056336 isRetracted "false" @default.
- W2032056336 magId "2032056336" @default.
- W2032056336 workType "article" @default.