FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032057105> ?p ?o ?g. }

• W2032057105 endingPage "293" @default.
• W2032057105 startingPage "285" @default.
• W2032057105 abstract "The role of the trans-acting factor HNF-1α in activating CYP2E1 gene expression was confirmed by transient co-transfection of an HNF-1α expression plasmid and the CYP2E1 promoter fused to the chloramphenicol acetyl transferase (CAT) reporter gene. Only HNF-1α, and not HNF-1β, HNF-4, C/EBPα, C/EBPβ, or DBP, was able to activate the CYP2E1 promoter. The extent of activation was proportional to the number of copies of the HNF-1 binding sequence upstream of the promoter. Removal or mutation of the HNF-1 binding sequence led to inactivation of the promoter in response to HNF-1α. Gel-shift Western blot analysis using a synthetic HNF-1 binding sequence derived from CYP2E1 and rat liver nuclear extract revealed that the protein–DNA complex obtained with adult rat liver nuclear extract consisted of both HNF-1α and HNF-1β proteins. The shifted bands produced by nuclear extracts from adult, where the endogenous CYP2E1 gene is active, and fetal rat liver, where the gene is inactive, were found to migrate differently, suggesting that the population of factors, possibly including different ratios of HNF-1α and HNF-1β proteins, may change during development. However, the co-transfection study did not show cooperativity between the two factors. Elements upstream of the HNF-1 binding site were found to affect the activity of the promoter negatively in the transfection assay. DNase I hypersensitive site mapping revealed a hypersensitive site in this inhibiting element in the adult rat liver sample but not in liver from newborn animals." @default.
• W2032057105 created "2016-06-24" @default.
• W2032057105 creator A5034021327 @default.
• W2032057105 creator A5073932699 @default.
• W2032057105 date "1995-04-01" @default.
• W2032057105 modified "2023-10-15" @default.
• W2032057105 title "Role of the Liver-Enriched Transcription Factor HNF-1α in Expression of the<i>CYP2E1</i>Gene" @default.
• W2032057105 cites W1457782476 @default.
• W2032057105 cites W1513797942 @default.
• W2032057105 cites W1559932979 @default.
• W2032057105 cites W1809161944 @default.
• W2032057105 cites W1903880433 @default.
• W2032057105 cites W1975045802 @default.
• W2032057105 cites W1978819530 @default.
• W2032057105 cites W1981286265 @default.
• W2032057105 cites W1993706334 @default.
• W2032057105 cites W2002886319 @default.
• W2032057105 cites W2005208850 @default.
• W2032057105 cites W2010400014 @default.
• W2032057105 cites W2011836510 @default.
• W2032057105 cites W201453924 @default.
• W2032057105 cites W2039307052 @default.
• W2032057105 cites W2047203795 @default.
• W2032057105 cites W2048356148 @default.
• W2032057105 cites W2060333964 @default.
• W2032057105 cites W2062423659 @default.
• W2032057105 cites W2066215499 @default.
• W2032057105 cites W2076134621 @default.
• W2032057105 cites W2083105603 @default.
• W2032057105 cites W2085064863 @default.
• W2032057105 cites W2087288778 @default.
• W2032057105 cites W2088927065 @default.
• W2032057105 cites W2090467716 @default.
• W2032057105 cites W2097794242 @default.
• W2032057105 cites W2126093778 @default.
• W2032057105 cites W2144206181 @default.
• W2032057105 cites W2144715892 @default.
• W2032057105 cites W2152295114 @default.
• W2032057105 cites W2205740461 @default.
• W2032057105 cites W295339133 @default.
• W2032057105 cites W4244969167 @default.
• W2032057105 doi "https://doi.org/10.1089/dna.1995.14.285" @default.
• W2032057105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7710685" @default.
• W2032057105 hasPublicationYear "1995" @default.
• W2032057105 type Work @default.
• W2032057105 sameAs 2032057105 @default.
• W2032057105 citedByCount "85" @default.
• W2032057105 countsByYear W20320571052012 @default.
• W2032057105 countsByYear W20320571052013 @default.
• W2032057105 countsByYear W20320571052014 @default.
• W2032057105 countsByYear W20320571052015 @default.
• W2032057105 countsByYear W20320571052016 @default.
• W2032057105 countsByYear W20320571052017 @default.
• W2032057105 countsByYear W20320571052018 @default.
• W2032057105 countsByYear W20320571052019 @default.
• W2032057105 countsByYear W20320571052020 @default.
• W2032057105 countsByYear W20320571052022 @default.
• W2032057105 countsByYear W20320571052023 @default.
• W2032057105 crossrefType "journal-article" @default.
• W2032057105 hasAuthorship W2032057105A5034021327 @default.
• W2032057105 hasAuthorship W2032057105A5073932699 @default.
• W2032057105 hasConcept C101762097 @default.
• W2032057105 hasConcept C104317684 @default.
• W2032057105 hasConcept C107824862 @default.
• W2032057105 hasConcept C150194340 @default.
• W2032057105 hasConcept C153911025 @default.
• W2032057105 hasConcept C161733203 @default.
• W2032057105 hasConcept C183978625 @default.
• W2032057105 hasConcept C54009773 @default.
• W2032057105 hasConcept C55493867 @default.
• W2032057105 hasConcept C86339819 @default.
• W2032057105 hasConcept C86803240 @default.
• W2032057105 hasConcept C99535661 @default.
• W2032057105 hasConceptScore W2032057105C101762097 @default.
• W2032057105 hasConceptScore W2032057105C104317684 @default.
• W2032057105 hasConceptScore W2032057105C107824862 @default.
• W2032057105 hasConceptScore W2032057105C150194340 @default.
• W2032057105 hasConceptScore W2032057105C153911025 @default.
• W2032057105 hasConceptScore W2032057105C161733203 @default.
• W2032057105 hasConceptScore W2032057105C183978625 @default.
• W2032057105 hasConceptScore W2032057105C54009773 @default.
• W2032057105 hasConceptScore W2032057105C55493867 @default.
• W2032057105 hasConceptScore W2032057105C86339819 @default.
• W2032057105 hasConceptScore W2032057105C86803240 @default.
• W2032057105 hasConceptScore W2032057105C99535661 @default.
• W2032057105 hasIssue "4" @default.
• W2032057105 hasLocation W20320571051 @default.
• W2032057105 hasLocation W20320571052 @default.
• W2032057105 hasOpenAccess W2032057105 @default.
• W2032057105 hasPrimaryLocation W20320571051 @default.
• W2032057105 hasRelatedWork W1994897973 @default.
• W2032057105 hasRelatedWork W2015590874 @default.
• W2032057105 hasRelatedWork W2017356642 @default.
• W2032057105 hasRelatedWork W2037827590 @default.
• W2032057105 hasRelatedWork W2106910951 @default.
• W2032057105 hasRelatedWork W2146517458 @default.
• W2032057105 hasRelatedWork W2352063489 @default.
• W2032057105 hasRelatedWork W2403366211 @default.

• next