FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032057778> ?p ?o ?g. }

• W2032057778 abstract "A number of peripheral blood analytes have been proposed as potential biomarkers of post-traumatic stress disorder (PTSD). Few studies have investigated whether observed changes in biomarkers persist over time. The aim of this study was to investigate the association of combat-related chronic PTSD with a wide array of putative PTSD biomarkers and to determine reliability of the measurements, i.e., correlations over time. Croatian combat veterans with chronic PTSD (n = 69) and age-matched healthy controls (n = 32), all men, were assessed at two time points separated by 3 months. Serum levels of lipids, cortisol, dehydroepiandrosterone-sulfate (DHEA-S), prolactin, and C-reactive protein were determined. Multiplex assay was used for the simultaneous assessment of 13 analytes in sera: cytokines [interferon-γ, interleukin (IL)-1β, IL-2, IL-4, IL-6, TNF-α], adhesion molecules (sPECAM-1, sICAM-1), chemokines (IL-8 and MIP-1α), sCD40L, nerve growth factor, and leptin. Group differences and changes over time were tested by parametric or non-parametric tests, including repeated measures analysis of covariance. Reliability estimates [intraclass correlation coefficient (ICC) and kappa] were also calculated. Robust associations of PTSD with higher levels of DHEA-S [F(1,75) = 8.14, p = 0.006)] and lower levels of prolactin [F(1,75) = 5.40, p = 0.023] were found. Measurements showed good to excellent reproducibility (DHEA-S, ICC = 0.50; prolactin, ICC = 0.79). Serum lipids did not differ between groups but significant increase of LDL-C after 3 months was observed in the PTSD group (t = 6.87, p < 0.001). IL-8 was lower in the PTSD group (t = 4.37, p < 0.001) but assessments showed poor reproducibility (ICC = -0.08). Stable DHEA-S and prolactin changes highlight their potential to be reliable markers of PTSD. Change in lipid profiles after 3 months suggests that PTSD patients may be more prone to hyperlipidemia. High intra-individual variability in some variables emphasizes the importance of longitudinal studies in investigations of PTSD biomarkers." @default.
• W2032057778 created "2016-06-24" @default.
• W2032057778 creator A5001262394 @default.
• W2032057778 creator A5008632261 @default.
• W2032057778 creator A5016572077 @default.
• W2032057778 creator A5023293805 @default.
• W2032057778 creator A5024216636 @default.
• W2032057778 creator A5040144637 @default.
• W2032057778 creator A5043283656 @default.
• W2032057778 creator A5063065464 @default.
• W2032057778 creator A5072775018 @default.
• W2032057778 date "2015-04-14" @default.
• W2032057778 modified "2023-09-23" @default.
• W2032057778 title "Circulating Levels of Hormones, Lipids, and Immune Mediators in Post-Traumatic Stress Disorder – A 3-Month Follow-Up Study" @default.
• W2032057778 cites W143274807 @default.
• W2032057778 cites W150865590 @default.
• W2032057778 cites W173911385 @default.
• W2032057778 cites W1966623608 @default.
• W2032057778 cites W1972411059 @default.
• W2032057778 cites W1974077278 @default.
• W2032057778 cites W1974331611 @default.
• W2032057778 cites W1978142592 @default.
• W2032057778 cites W1982301384 @default.
• W2032057778 cites W1984776877 @default.
• W2032057778 cites W1984783815 @default.
• W2032057778 cites W1985164491 @default.
• W2032057778 cites W1989618975 @default.
• W2032057778 cites W1990652217 @default.
• W2032057778 cites W1991131705 @default.
• W2032057778 cites W1993010501 @default.
• W2032057778 cites W1993013946 @default.
• W2032057778 cites W2000811236 @default.
• W2032057778 cites W2000987296 @default.
• W2032057778 cites W2001986928 @default.
• W2032057778 cites W2002697344 @default.
• W2032057778 cites W2002950827 @default.
• W2032057778 cites W2008305355 @default.
• W2032057778 cites W2014520755 @default.
• W2032057778 cites W2015595848 @default.
• W2032057778 cites W2020626300 @default.
• W2032057778 cites W2023045431 @default.
• W2032057778 cites W2024181736 @default.
• W2032057778 cites W2028573458 @default.
• W2032057778 cites W2031358273 @default.
• W2032057778 cites W2037124611 @default.
• W2032057778 cites W2037339567 @default.
• W2032057778 cites W2037485827 @default.
• W2032057778 cites W2039297066 @default.
• W2032057778 cites W2040975346 @default.
• W2032057778 cites W2042430625 @default.
• W2032057778 cites W2043275406 @default.
• W2032057778 cites W2046446693 @default.
• W2032057778 cites W2046796005 @default.
• W2032057778 cites W2048860852 @default.
• W2032057778 cites W2051176540 @default.
• W2032057778 cites W2052422532 @default.
• W2032057778 cites W2052819755 @default.
• W2032057778 cites W2052959069 @default.
• W2032057778 cites W2056786635 @default.
• W2032057778 cites W2060124746 @default.
• W2032057778 cites W2063694580 @default.
• W2032057778 cites W2066125403 @default.
• W2032057778 cites W2067907418 @default.
• W2032057778 cites W2068720795 @default.
• W2032057778 cites W2070362655 @default.
• W2032057778 cites W2070816723 @default.
• W2032057778 cites W2072086451 @default.
• W2032057778 cites W2076195665 @default.
• W2032057778 cites W2077326058 @default.
• W2032057778 cites W2080900225 @default.
• W2032057778 cites W2082096285 @default.
• W2032057778 cites W2083675778 @default.
• W2032057778 cites W2092238952 @default.
• W2032057778 cites W2093982682 @default.
• W2032057778 cites W2094316730 @default.
• W2032057778 cites W2097775881 @default.
• W2032057778 cites W2100407763 @default.
• W2032057778 cites W2101297040 @default.
• W2032057778 cites W2103198151 @default.
• W2032057778 cites W2104353822 @default.
• W2032057778 cites W2109367568 @default.
• W2032057778 cites W2113340035 @default.
• W2032057778 cites W2114418219 @default.
• W2032057778 cites W2115094271 @default.
• W2032057778 cites W2115742753 @default.
• W2032057778 cites W2118377872 @default.
• W2032057778 cites W2119644635 @default.
• W2032057778 cites W2125221366 @default.
• W2032057778 cites W2125978074 @default.
• W2032057778 cites W2128571125 @default.
• W2032057778 cites W2131761641 @default.
• W2032057778 cites W2137959792 @default.
• W2032057778 cites W2139825658 @default.
• W2032057778 cites W2147984677 @default.
• W2032057778 cites W2158809703 @default.
• W2032057778 cites W2159778244 @default.
• W2032057778 cites W2163857054 @default.
• W2032057778 cites W2170385767 @default.
• W2032057778 cites W2170834410 @default.
• W2032057778 cites W2187671036 @default.

• next