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- W2032060250 abstract "Peptide nitriles are reversible inhibitors of papain that form thioimidates with the cysteine thiol in the enzyme's active site. These thioimidates undergo reactions with thiols and amines to form acids and amidines, respectively. These reactions were also found to be stereospecific. Only a thioimidate derived from an L-amino acid nitrile will react with exogenous nucleophiles. These reactions were followed by 13 C and 15 N NMR techniques. Key words: papain, nitrile, l3 C NMR, 15 N NMR, thioimidate." @default.
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- W2032060250 date "1991-08-01" @default.
- W2032060250 modified "2023-10-14" @default.
- W2032060250 title "Inhibition of papain by peptide nitriles: conversion of the nitrile group into other functionalities via the papain:nitrile thioimidate ester adduct" @default.
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- W2032060250 doi "https://doi.org/10.1139/v91-192" @default.
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