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- W2032060551 abstract "Since the discovery of the CD40-CD154 costimulatory pathway and its critical role in the adaptive immune response, there has been considerable interest in therapeutically targeting this interaction with monoclonal antibodies in transplantation. Unfortunately, initial promise in animal models gave way to disappointment in clinical trials following a number of thromboembolic complications. However, recent mechanistic studies have identified the mechanism of these adverse events, as well as detailed a myriad of interactions between CD40 and CD154 on a wide variety of immune cell types and the critical role of this pathway in generating both humoral and cell-mediated alloreactive responses. This has led to resurgence in interest and the potential resurrection of anti-CD154 and anti-CD40 antibodies as clinically viable therapeutic options." @default.
- W2032060551 created "2016-06-24" @default.
- W2032060551 creator A5003683161 @default.
- W2032060551 creator A5087476769 @default.
- W2032060551 date "2015-04-01" @default.
- W2032060551 modified "2023-10-13" @default.
- W2032060551 title "Novel insights into anti-CD40/CD154 immunotherapy in transplant tolerance" @default.
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- W2032060551 doi "https://doi.org/10.2217/imt.15.1" @default.
- W2032060551 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5441999" @default.
- W2032060551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25917630" @default.
- W2032060551 hasPublicationYear "2015" @default.
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