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- W2032061786 abstract "In the presence of bicuculline and/or picrotoxin (−)-baclofen and γ-aminobutyric acid (GABA) induced outward currents (IBac and IGABA) at holding potentials of −55 to −75 mV in guinea pig CA3 neurones of hippocampal slices. Zero potentials for these currents were at the K-equilibrium potential indicating that they were carried by K-ions (IK,Bac, IK,GABA). IK,Bac was strongly reduced by carbachol (Cch) in low concentration (0.1–0.3 μM), while IK,GABA was not affected by Cch concentrations even up to 20 μM. The K-dependent late inhibitory postsynaptic potential (IPSP) was reduced significantly by Cch concentrations higher than 1 μM, but with these concentrations the early, Cl-dependent IPSP was reduced as well. The baclofen-derivative phaclofen, considered a selective antagonist of both the postsynaptic action of baclofen and the bicuculline — and picrotoxin — resistant action of GABA, exhibited, in our hands, partial agonistic effects and effects on non-transmitter gated K-currents. Our findings cast some doubt on the assumption that IK,Bac, IK,GABA and the late IPSP are all mediated by the same receptor and generated by the same mechanism." @default.
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- W2032061786 date "1989-07-01" @default.
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- W2032061786 title "Carbachol reduces IK,Baclofen, but not IK,GABA in guinea pig hippocampal slices" @default.
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- W2032061786 doi "https://doi.org/10.1016/0304-3940(89)90083-9" @default.
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