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• W2032064883 abstract "Compounds that are all HAART: Subsequent to accessing the S2 subpocket of HIV protease from the novel lysinol series of HIV protease inhibitors, we now report a comprehensive structure–activity relationship study at this position. Balancing physical properties via truncation of the substituent binding in the S1′ subpocket enabled the discovery of inhibitors with improved pharmacokinetic properties, while maintaining the functional potency of these inhibitors." @default.
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• W2032064883 date "2010-12-29" @default.
• W2032064883 modified "2023-10-09" @default.
• W2032064883 title "Strategies towards Improving the Pharmacokinetic Profile of ε-Substituted Lysinol-Derived HIV Protease Inhibitors" @default.
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• W2032064883 doi "https://doi.org/10.1002/cmdc.201000395" @default.
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