FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032068252> ?p ?o ?g. }

• W2032068252 endingPage "14" @default.
• W2032068252 startingPage "1" @default.
• W2032068252 abstract "Sini decoction is a well-known formula of traditional Chinese medicine, which has been used to treat cardiovascular disease for many years. Previously, we demonstrated that Sini decoction prevented doxorubicin-induced heart failure in vivo. However, its active components are still unclear. Thus, we investigated the active components of Sini decoction and their cardioprotective mechanisms in the in vitro neonatal rat cardiomyocytes and H9c2 cell line models of doxorubicin-induced cytotoxicity. Our results demonstrated that treatment with higenamine or [6]-gingerol increased viability of doxorubicine-injured cardiomyocytes. Moreover, combined use of higenamine and [6]-gingerol exerted more profound protective effects than either drug as a single agent, with effects similar to those of dexrazoxane, a clinically approved cardiac protective agent. In addition, we found that treatment with doxorubicin reduced SOD activity, increased ROS generation, enhanced MDA formation, induced release of LDH, and triggered the intrinsic mitochondria-dependent apoptotic pathway in cardiomyocytes, which was inhibited by cotreatment of higenamine and [6]-gingerol. Most importantly, the cytoprotection of higenamine plus [6]-gingerol could be abrogated by LY294002, a PI3K inhibitor. In conclusion, combination of higenamine and [6]-gingerol exerts cardioprotective effect against doxorubicin-induced cardiotoxicity through activating the PI3K/Akt signaling pathway. Higenamine and [6]-gingerol may be the active components of Sini decoction." @default.
• W2032068252 created "2016-06-24" @default.
• W2032068252 creator A5008999201 @default.
• W2032068252 creator A5014859221 @default.
• W2032068252 creator A5019641145 @default.
• W2032068252 creator A5030361370 @default.
• W2032068252 creator A5037817685 @default.
• W2032068252 creator A5062627778 @default.
• W2032068252 creator A5079940252 @default.
• W2032068252 date "2013-01-01" @default.
• W2032068252 modified "2023-10-17" @default.
• W2032068252 title "Higenamine Combined with [6]-Gingerol Suppresses Doxorubicin-Triggered Oxidative Stress and Apoptosis in Cardiomyocytes via Upregulation of PI3K/Akt Pathway" @default.
• W2032068252 cites W1964325985 @default.
• W2032068252 cites W1967389878 @default.
• W2032068252 cites W1968351069 @default.
• W2032068252 cites W1972554642 @default.
• W2032068252 cites W1973856927 @default.
• W2032068252 cites W1982181214 @default.
• W2032068252 cites W1989175790 @default.
• W2032068252 cites W1996147899 @default.
• W2032068252 cites W1997849655 @default.
• W2032068252 cites W2006793476 @default.
• W2032068252 cites W2008125875 @default.
• W2032068252 cites W2011477614 @default.
• W2032068252 cites W2014063249 @default.
• W2032068252 cites W2017455950 @default.
• W2032068252 cites W2028557451 @default.
• W2032068252 cites W2040392265 @default.
• W2032068252 cites W2040873954 @default.
• W2032068252 cites W2047663493 @default.
• W2032068252 cites W2048984213 @default.
• W2032068252 cites W2049051081 @default.
• W2032068252 cites W2056441912 @default.
• W2032068252 cites W2067470115 @default.
• W2032068252 cites W2071479387 @default.
• W2032068252 cites W2075035979 @default.
• W2032068252 cites W2080829192 @default.
• W2032068252 cites W2089571568 @default.
• W2032068252 cites W2089923455 @default.
• W2032068252 cites W2090168914 @default.
• W2032068252 cites W2104238143 @default.
• W2032068252 cites W2130866079 @default.
• W2032068252 cites W2140182328 @default.
• W2032068252 cites W2150562016 @default.
• W2032068252 cites W2162250897 @default.
• W2032068252 cites W2167293805 @default.
• W2032068252 cites W4312861576 @default.
• W2032068252 doi "https://doi.org/10.1155/2013/970490" @default.
• W2032068252 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3687593" @default.
• W2032068252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23861719" @default.
• W2032068252 hasPublicationYear "2013" @default.
• W2032068252 type Work @default.
• W2032068252 sameAs 2032068252 @default.
• W2032068252 citedByCount "23" @default.
• W2032068252 countsByYear W20320682522014 @default.
• W2032068252 countsByYear W20320682522015 @default.
• W2032068252 countsByYear W20320682522016 @default.
• W2032068252 countsByYear W20320682522017 @default.
• W2032068252 countsByYear W20320682522018 @default.
• W2032068252 countsByYear W20320682522019 @default.
• W2032068252 countsByYear W20320682522020 @default.
• W2032068252 countsByYear W20320682522021 @default.
• W2032068252 countsByYear W20320682522022 @default.
• W2032068252 countsByYear W20320682522023 @default.
• W2032068252 crossrefType "journal-article" @default.
• W2032068252 hasAuthorship W2032068252A5008999201 @default.
• W2032068252 hasAuthorship W2032068252A5014859221 @default.
• W2032068252 hasAuthorship W2032068252A5019641145 @default.
• W2032068252 hasAuthorship W2032068252A5030361370 @default.
• W2032068252 hasAuthorship W2032068252A5037817685 @default.
• W2032068252 hasAuthorship W2032068252A5062627778 @default.
• W2032068252 hasAuthorship W2032068252A5079940252 @default.
• W2032068252 hasBestOaLocation W20320682521 @default.
• W2032068252 hasConcept C121608353 @default.
• W2032068252 hasConcept C126322002 @default.
• W2032068252 hasConcept C150903083 @default.
• W2032068252 hasConcept C185592680 @default.
• W2032068252 hasConcept C190283241 @default.
• W2032068252 hasConcept C207001950 @default.
• W2032068252 hasConcept C2776039994 @default.
• W2032068252 hasConcept C2776151105 @default.
• W2032068252 hasConcept C2776694085 @default.
• W2032068252 hasConcept C2776802502 @default.
• W2032068252 hasConcept C2776912716 @default.
• W2032068252 hasConcept C2778233292 @default.
• W2032068252 hasConcept C2779720357 @default.
• W2032068252 hasConcept C2781303535 @default.
• W2032068252 hasConcept C43617362 @default.
• W2032068252 hasConcept C530470458 @default.
• W2032068252 hasConcept C55493867 @default.
• W2032068252 hasConcept C71924100 @default.
• W2032068252 hasConcept C75217442 @default.
• W2032068252 hasConcept C86554907 @default.
• W2032068252 hasConcept C86803240 @default.
• W2032068252 hasConcept C98274493 @default.
• W2032068252 hasConceptScore W2032068252C121608353 @default.
• W2032068252 hasConceptScore W2032068252C126322002 @default.
• W2032068252 hasConceptScore W2032068252C150903083 @default.

• next