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- W2032069083 abstract "La transformation maligne d’une papillomatose laryngée juvénile est rare et les cas rapportés ont été essentiellement observés chez l’adulte. Nous rapportons le cas d’une enfant de 15 ans décédée d’un cancer bronchopulmonaire avec envahissement péricardique développé à partir d’une papillomatose laryngée juvénile. Un papillomavirus humain (HPV) de type 11 a été identifié dans les papillomes nasopharyngés et trachéaux ainsi que dans le liquide péricardique. Le séquençage des gènes E1, E2, E4, E6 et E7 de HPV 11, ainsi que le séquençage des exons 5 à 9 du gène de la protéine P53 de cette adolescente n’ont pas permis d’identifier de mutations pouvant être associées à cette transformation maligne. Cette observation confirme que la transformation maligne d’une papillomatose laryngée juvénile peut survenir chez l’enfant. Le rôle carcinogène de HPV 11 dans ce contexte reste encore à élucider. Malignant transformation of juvenile-onset recurrent respiratory papillomatosis (RRP) is a rare event and the cases reported have been mainly observed in adults. We report the case of a 15-year-old girl with a history of severe RRP who died of a HPV 11-associated bronchopulmonary squamous cell carcinoma with pericardial invasion. HPV 11 was identified in nasopharyngeal and tracheal papillomas, as well as in the pericardial fluid. HPV 11 isolate was further analyzed by amplification and sequencing of the E1, E2, E4, E6, and E7 genes. Only one amino acid substitution in E4 due to natural polymorphism was observed. Exons 5–9 of the patient's tumor protein 53 (TP53) gene were sequenced and no mutations were identified. This observation confirms that malignant conversion of juvenile-onset RRP associated with HPV 11 to squamous cell carcinoma may arise in children. HPV 11-induced carcinogenesis needs to be further investigated." @default.
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- W2032069083 date "2011-07-01" @default.
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- W2032069083 title "Papillomatose laryngée sévère évoluant vers un carcinome bronchopulmonaire associé à HPV 11 chez une enfant de 15 ans : à propos d’un cas" @default.
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- W2032069083 doi "https://doi.org/10.1016/j.arcped.2011.04.013" @default.
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