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• W2032069645 abstract "Aims Our aim was to study the effect of grapefruit juice on the pharmacokinetics of levothyroxine. Methods In a randomized cross-over study with two phases, 10 healthy subjects ingested 200 ml grapefruit juice or water (control) three times daily for 2 days. On day 3, a single 600 µg dose of levothyroxine was administered with 200 ml grapefruit juice or water, which was also ingested 1 h before and 1 h after levothyroxine. Serum concentrations of total thyroxine (T4) and thyroid-stimulating hormone (TSH) were measured up to 24 h. Results Grapefruit juice decreased slightly (11%; P < 0.01) the maximal increase of T4 concentration after ingestion of levothyroxine from 66.4 nmol l−1 to 59.4 nmol l−1 (95% CI on the difference −11.3, −2.7). The incremental areas under the serum T4 concentration-time curve (dAUC) during the first 4 and 6 h were also decreased slightly: dAUC(0,4 h) by 13% (P < 0.05), from 195 nmol l−1 h to 169 nmol l−1 h (95% CI −51, −1) and dAUC(0,6 h) by 9% (P = 0.085), from 298 nmol l−1 h to 271 nmol l−1 h (95% CI −58, 4). The decrease in the serum concentration of TSH (1.25 mU l−1) measured 24 h after ingestion of levothyroxine, was not altered by grapefruit juice. Conclusions Grapefruit juice may slightly delay the absorption of levothyroxine, but it seems to have only a minor effect on its bioavailability. Accordingly, the clinical relevance of the grapefruit juice-levothyroxine interaction is likely to be small." @default.
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• W2032069645 date "2005-09-01" @default.
• W2032069645 modified "2023-10-17" @default.
• W2032069645 title "Effects of grapefruit juice on the absorption of levothyroxine" @default.
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• W2032069645 doi "https://doi.org/10.1111/j.1365-2125.2005.02433.x" @default.
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