FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032077536> ?p ?o ?g. }

• W2032077536 endingPage "374" @default.
• W2032077536 startingPage "367" @default.
• W2032077536 abstract "Black people have a higher propensity than caucasians toward essential hypertension. To explore the possibility that this racial difference relates to cellular Ca2+ metabolism, we measured 45Ca2+ washout and uptake and cytosolic free concentration of Ca2+ [Ca2+]i in serially passed skin fibroblasts from normotensive black and white males. Depending on the experimental conditions, 45Ca2+ washout in these cells was described by either two or three exponential functions, whereas 45Ca2+ uptake was described only by a two-exponent function. There were no racial differences in 45Ca2+ uptake and washout of unstimulated fibroblasts. However, stimulation by human serum resulted in an increase in the 45Ca2+ washout that was higher in fibroblasts from blacks than from whites. The racial differences were expressed primarily by higher values of the apparent washout rate constant (k1) of 45Ca2+ from the largest and most rapidly exchangeable cellular pool. The effect of human serum was not related to its origin (blacks vs. whites). In 2 mM Ca2+ medium and 10% serum from blacks, the respective k1 (mean +/- SEM; x 10(-2)/min) values for fibroblasts from blacks and whites were 89.68 +/- 5.23 and 73.29 +/- 4.0; in the presence of 10% serum from whites, the k1 values for cells from blacks and whites were 84.14 +/- 2.80 and 76.36 +/- 3.23 (overall significance of P less than .01). In Ca2+-deficient medium in the presence of 10% human serum, the k1 for fibroblasts from blacks and whites were 115.57 +/- 3.76 and 102.15 +/- 3.30 (P less than .05). Serum substantially increased the 45Ca2+ uptake in fibroblasts from both blacks and whites; however, racial differences were not observed. Basal levels of [Ca2+]i were not different in fibroblasts of blacks vs. whites (46.8 +/- 6.8 and 43.2 +/- 7.1 nM for blacks and whites, respectively). However, the peak response of Cai2+ transients for cell stimulated by 5% human serum was significantly higher in blacks than whites (blacks = 963 +/- 213, whites = 481 +/- 162 nM; P = .0286). We conclude that Ca2+ regulation is different in serum-stimulated fibroblasts from blacks and whites and that, at least in part, this difference may relate to a greater agonist-induced mobilization of Ca2+ in fibroblasts from blacks." @default.
• W2032077536 created "2016-06-24" @default.
• W2032077536 creator A5014564343 @default.
• W2032077536 creator A5038567756 @default.
• W2032077536 creator A5042990697 @default.
• W2032077536 creator A5048847393 @default.
• W2032077536 creator A5076306047 @default.
• W2032077536 creator A5079096007 @default.
• W2032077536 date "1989-02-01" @default.
• W2032077536 modified "2023-09-26" @default.
• W2032077536 title "Differences of Ca2+ regulation in skin fibroblasts from blacks and whites" @default.
• W2032077536 cites W1489663455 @default.
• W2032077536 cites W1518719712 @default.
• W2032077536 cites W1527715380 @default.
• W2032077536 cites W1586939748 @default.
• W2032077536 cites W1598093499 @default.
• W2032077536 cites W1714452414 @default.
• W2032077536 cites W1899699449 @default.
• W2032077536 cites W1947794470 @default.
• W2032077536 cites W1965526093 @default.
• W2032077536 cites W1978508573 @default.
• W2032077536 cites W1980262844 @default.
• W2032077536 cites W1994714150 @default.
• W2032077536 cites W1996289114 @default.
• W2032077536 cites W2000020431 @default.
• W2032077536 cites W2000392454 @default.
• W2032077536 cites W2001561174 @default.
• W2032077536 cites W2016106068 @default.
• W2032077536 cites W2017822767 @default.
• W2032077536 cites W2018084198 @default.
• W2032077536 cites W2031206611 @default.
• W2032077536 cites W2036241874 @default.
• W2032077536 cites W2036360711 @default.
• W2032077536 cites W2036746658 @default.
• W2032077536 cites W2038500363 @default.
• W2032077536 cites W2045235248 @default.
• W2032077536 cites W2045594638 @default.
• W2032077536 cites W2051511265 @default.
• W2032077536 cites W2059778014 @default.
• W2032077536 cites W2063158991 @default.
• W2032077536 cites W2063771109 @default.
• W2032077536 cites W2065358610 @default.
• W2032077536 cites W2066960472 @default.
• W2032077536 cites W2068387513 @default.
• W2032077536 cites W2078440133 @default.
• W2032077536 cites W2085580848 @default.
• W2032077536 cites W2086664787 @default.
• W2032077536 cites W2089806899 @default.
• W2032077536 cites W2090231869 @default.
• W2032077536 cites W2141260882 @default.
• W2032077536 cites W2148854096 @default.
• W2032077536 cites W2171872846 @default.
• W2032077536 cites W2268031474 @default.
• W2032077536 cites W2319437148 @default.
• W2032077536 cites W2328891110 @default.
• W2032077536 cites W2329781414 @default.
• W2032077536 cites W2411400632 @default.
• W2032077536 doi "https://doi.org/10.1002/jcp.1041380220" @default.
• W2032077536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2918038" @default.
• W2032077536 hasPublicationYear "1989" @default.
• W2032077536 type Work @default.
• W2032077536 sameAs 2032077536 @default.
• W2032077536 citedByCount "15" @default.
• W2032077536 crossrefType "journal-article" @default.
• W2032077536 hasAuthorship W2032077536A5014564343 @default.
• W2032077536 hasAuthorship W2032077536A5038567756 @default.
• W2032077536 hasAuthorship W2032077536A5042990697 @default.
• W2032077536 hasAuthorship W2032077536A5048847393 @default.
• W2032077536 hasAuthorship W2032077536A5076306047 @default.
• W2032077536 hasAuthorship W2032077536A5079096007 @default.
• W2032077536 hasConcept C107130276 @default.
• W2032077536 hasConcept C126322002 @default.
• W2032077536 hasConcept C134018914 @default.
• W2032077536 hasConcept C16685009 @default.
• W2032077536 hasConcept C181199279 @default.
• W2032077536 hasConcept C185592680 @default.
• W2032077536 hasConcept C202751555 @default.
• W2032077536 hasConcept C24998067 @default.
• W2032077536 hasConcept C2780381497 @default.
• W2032077536 hasConcept C2781222467 @default.
• W2032077536 hasConcept C55493867 @default.
• W2032077536 hasConcept C71839028 @default.
• W2032077536 hasConcept C71924100 @default.
• W2032077536 hasConcept C86803240 @default.
• W2032077536 hasConcept C98539663 @default.
• W2032077536 hasConceptScore W2032077536C107130276 @default.
• W2032077536 hasConceptScore W2032077536C126322002 @default.
• W2032077536 hasConceptScore W2032077536C134018914 @default.
• W2032077536 hasConceptScore W2032077536C16685009 @default.
• W2032077536 hasConceptScore W2032077536C181199279 @default.
• W2032077536 hasConceptScore W2032077536C185592680 @default.
• W2032077536 hasConceptScore W2032077536C202751555 @default.
• W2032077536 hasConceptScore W2032077536C24998067 @default.
• W2032077536 hasConceptScore W2032077536C2780381497 @default.
• W2032077536 hasConceptScore W2032077536C2781222467 @default.
• W2032077536 hasConceptScore W2032077536C55493867 @default.
• W2032077536 hasConceptScore W2032077536C71839028 @default.
• W2032077536 hasConceptScore W2032077536C71924100 @default.

• next