Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032078116> ?p ?o ?g. }
- W2032078116 abstract "Cdc42 regulates the initial establishment of cytoskeletal and junctional structures, but only little is known about its role at later stages of cellular differentiation. We studied Cdc42's role in vivo in auditory supporting cells, epithelial cells with high structural complexity. Cdc42 inactivation was induced early postnatally using the Cdc42(loxP/loxP);Fgfr3-iCre-ER(T2) mice. Cdc42 depletion impaired elongation of adherens junctions and F-actin belts, leading to constriction of the sensory epithelial surface. Fragmented F-actin belts, junctions containing ectopic lumens and misexpression of a basolateral membrane protein in the apical domain were observed. These defects and changes in aPKCλ/ι expression suggested that apical polarization is impaired. Following a lesion at adulthood, supporting cells with Cdc42 loss-induced maturational defects collapsed and failed to remodel F-actin belts, a process that is critical to scar formation. Thus, Cdc42 is required for structural differentiation of auditory supporting cells and this proper maturation is necessary for wound healing in adults." @default.
- W2032078116 created "2016-06-24" @default.
- W2032078116 creator A5002633839 @default.
- W2032078116 creator A5007270321 @default.
- W2032078116 creator A5015335572 @default.
- W2032078116 creator A5038418840 @default.
- W2032078116 creator A5051320433 @default.
- W2032078116 creator A5058389354 @default.
- W2032078116 creator A5071433852 @default.
- W2032078116 creator A5089430130 @default.
- W2032078116 date "2012-12-17" @default.
- W2032078116 modified "2023-09-27" @default.
- W2032078116 title "Cdc42-dependent structural development of auditory supporting cells is required for wound healing at adulthood" @default.
- W2032078116 cites W124406007 @default.
- W2032078116 cites W162484059 @default.
- W2032078116 cites W1965593148 @default.
- W2032078116 cites W1972200274 @default.
- W2032078116 cites W1972204116 @default.
- W2032078116 cites W1972509102 @default.
- W2032078116 cites W1977245174 @default.
- W2032078116 cites W1981518793 @default.
- W2032078116 cites W1983314786 @default.
- W2032078116 cites W1983708909 @default.
- W2032078116 cites W1983986827 @default.
- W2032078116 cites W1984024996 @default.
- W2032078116 cites W1998457769 @default.
- W2032078116 cites W1999611910 @default.
- W2032078116 cites W2003889355 @default.
- W2032078116 cites W2004851934 @default.
- W2032078116 cites W2008422345 @default.
- W2032078116 cites W2008742718 @default.
- W2032078116 cites W2030239298 @default.
- W2032078116 cites W2031274213 @default.
- W2032078116 cites W2031735932 @default.
- W2032078116 cites W2033555492 @default.
- W2032078116 cites W2034405959 @default.
- W2032078116 cites W2038665424 @default.
- W2032078116 cites W2039962130 @default.
- W2032078116 cites W2046365944 @default.
- W2032078116 cites W2047091450 @default.
- W2032078116 cites W2047727235 @default.
- W2032078116 cites W2049384154 @default.
- W2032078116 cites W2050858182 @default.
- W2032078116 cites W2059159629 @default.
- W2032078116 cites W2071199281 @default.
- W2032078116 cites W2076255441 @default.
- W2032078116 cites W2077886251 @default.
- W2032078116 cites W2087378033 @default.
- W2032078116 cites W2090114628 @default.
- W2032078116 cites W2094803625 @default.
- W2032078116 cites W2099243834 @default.
- W2032078116 cites W2100338747 @default.
- W2032078116 cites W2104135721 @default.
- W2032078116 cites W2113806708 @default.
- W2032078116 cites W2115094414 @default.
- W2032078116 cites W2119648960 @default.
- W2032078116 cites W2119711419 @default.
- W2032078116 cites W2124725230 @default.
- W2032078116 cites W2128826029 @default.
- W2032078116 cites W2129460080 @default.
- W2032078116 cites W2138776554 @default.
- W2032078116 cites W2143951787 @default.
- W2032078116 cites W2146247758 @default.
- W2032078116 cites W2154665940 @default.
- W2032078116 cites W2163412135 @default.
- W2032078116 cites W2167757351 @default.
- W2032078116 cites W2991811311 @default.
- W2032078116 cites W4300465941 @default.
- W2032078116 doi "https://doi.org/10.1038/srep00978" @default.
- W2032078116 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3523287" @default.
- W2032078116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23248743" @default.
- W2032078116 hasPublicationYear "2012" @default.
- W2032078116 type Work @default.
- W2032078116 sameAs 2032078116 @default.
- W2032078116 citedByCount "31" @default.
- W2032078116 countsByYear W20320781162013 @default.
- W2032078116 countsByYear W20320781162014 @default.
- W2032078116 countsByYear W20320781162015 @default.
- W2032078116 countsByYear W20320781162016 @default.
- W2032078116 countsByYear W20320781162017 @default.
- W2032078116 countsByYear W20320781162018 @default.
- W2032078116 countsByYear W20320781162019 @default.
- W2032078116 countsByYear W20320781162020 @default.
- W2032078116 countsByYear W20320781162021 @default.
- W2032078116 countsByYear W20320781162023 @default.
- W2032078116 crossrefType "journal-article" @default.
- W2032078116 hasAuthorship W2032078116A5002633839 @default.
- W2032078116 hasAuthorship W2032078116A5007270321 @default.
- W2032078116 hasAuthorship W2032078116A5015335572 @default.
- W2032078116 hasAuthorship W2032078116A5038418840 @default.
- W2032078116 hasAuthorship W2032078116A5051320433 @default.
- W2032078116 hasAuthorship W2032078116A5058389354 @default.
- W2032078116 hasAuthorship W2032078116A5071433852 @default.
- W2032078116 hasAuthorship W2032078116A5089430130 @default.
- W2032078116 hasBestOaLocation W20320781161 @default.
- W2032078116 hasConcept C105702510 @default.
- W2032078116 hasConcept C125705527 @default.
- W2032078116 hasConcept C142669718 @default.
- W2032078116 hasConcept C1491633281 @default.
- W2032078116 hasConcept C149402561 @default.