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- W2032079892 abstract "Multipotential bone marrow mesenchymal stem cells (BMSCs) are important in maintaining the microenvironment of the bone marrow (BM). Sympathetic nerves histologically innervate the BM; however, their role remains unclear. In this study, the effects of norepinephrine on DNA synthesis and the related signaling molecules involved in rBMSCs were examined. mRNA levels of the α1-adrenergic receptor subtypes increased following norepinephrine stimulation (10−5 M for 30 min). DNA synthesis increased in dose- and time-dependent manners as determined by [3H]thymidine incorporation. Intracellular Ca2+ concentration and translocation of protein kinase C from the cytosol to the membrane were also found to be elevated in rBMSCs. Phentolamine was able to suppress translocation of PKC. Norepinephrine also induced phosphorylation of ERK1/2, which was prevented by staurosporine treatment. Pretreatment with PD98059 inhibited ERK1/2 phosphorylation and DNA synthesis in rBMSCs. These findings indicate that norepinephrine stimulates DNA synthesis via α1-adrenergic receptors and downstream Ca2+/PKC and ERK1/2 activation in rBMSCs." @default.
- W2032079892 created "2016-06-24" @default.
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- W2032079892 date "2009-10-01" @default.
- W2032079892 modified "2023-10-15" @default.
- W2032079892 title "DNA synthesis of rat bone marrow mesenchymal stem cells through α1-adrenergic receptors" @default.
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- W2032079892 doi "https://doi.org/10.1016/j.abb.2009.08.009" @default.
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