Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032081637> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2032081637 endingPage "12521" @default.
- W2032081637 startingPage "12512" @default.
- W2032081637 abstract "Three structures of saccharopine dehydrogenase (l-lysine-forming) (SDH) have been determined in the presence of sulfate, adenosine monophosphate (AMP), and oxalylglycine (OxGly). In the sulfate-bound structure, a sulfate ion binds in a cleft between the two domains of SDH, occupies one of the substrate carboxylate binding sites, and results in partial closure of the active site of the enzyme due to a domain rotation of almost 12° in comparison to the apoenzyme structure. In the second structure, AMP binds to the active site in an area where the NAD+ cofactor is expected to bind. All of the AMP moieties (adenine ring, ribose, and phosphate) interact with specific residues of the enzyme. In the OxGly-bound structure, carboxylates of OxGly interact with arginine residues representative of the manner in which substrate (α-ketoglutarate and saccharopine) may bind. The α-keto group of OxGly interacts with Lys77 and His96, which are candidates for acid−base catalysis. Analysis of ligand−enzyme interactions, comparative structural analysis, corroboration with kinetic data, and discussion of a ternary complex model are presented in this study." @default.
- W2032081637 created "2016-06-24" @default.
- W2032081637 creator A5022124972 @default.
- W2032081637 creator A5037912029 @default.
- W2032081637 creator A5082906519 @default.
- W2032081637 creator A5083342965 @default.
- W2032081637 date "2007-10-16" @default.
- W2032081637 modified "2023-10-18" @default.
- W2032081637 title "Crystal Structures of Ligand-Bound Saccharopine Dehydrogenase from <i>Saccharomyces cerevisiae</i><sup>,</sup>" @default.
- W2032081637 cites W1546997790 @default.
- W2032081637 cites W1647606491 @default.
- W2032081637 cites W1756233575 @default.
- W2032081637 cites W1986191025 @default.
- W2032081637 cites W2000358752 @default.
- W2032081637 cites W2135839939 @default.
- W2032081637 doi "https://doi.org/10.1021/bi701428m" @default.
- W2032081637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17939687" @default.
- W2032081637 hasPublicationYear "2007" @default.
- W2032081637 type Work @default.
- W2032081637 sameAs 2032081637 @default.
- W2032081637 citedByCount "19" @default.
- W2032081637 countsByYear W20320816372012 @default.
- W2032081637 countsByYear W20320816372013 @default.
- W2032081637 countsByYear W20320816372015 @default.
- W2032081637 countsByYear W20320816372018 @default.
- W2032081637 countsByYear W20320816372020 @default.
- W2032081637 countsByYear W20320816372021 @default.
- W2032081637 countsByYear W20320816372022 @default.
- W2032081637 countsByYear W20320816372023 @default.
- W2032081637 crossrefType "journal-article" @default.
- W2032081637 hasAuthorship W2032081637A5022124972 @default.
- W2032081637 hasAuthorship W2032081637A5037912029 @default.
- W2032081637 hasAuthorship W2032081637A5082906519 @default.
- W2032081637 hasAuthorship W2032081637A5083342965 @default.
- W2032081637 hasConcept C107824862 @default.
- W2032081637 hasConcept C116569031 @default.
- W2032081637 hasConcept C170493617 @default.
- W2032081637 hasConcept C181199279 @default.
- W2032081637 hasConcept C185592680 @default.
- W2032081637 hasConcept C18903297 @default.
- W2032081637 hasConcept C197957613 @default.
- W2032081637 hasConcept C2777289219 @default.
- W2032081637 hasConcept C2779268744 @default.
- W2032081637 hasConcept C2779461342 @default.
- W2032081637 hasConcept C41183919 @default.
- W2032081637 hasConcept C55493867 @default.
- W2032081637 hasConcept C71240020 @default.
- W2032081637 hasConcept C86756495 @default.
- W2032081637 hasConcept C86803240 @default.
- W2032081637 hasConceptScore W2032081637C107824862 @default.
- W2032081637 hasConceptScore W2032081637C116569031 @default.
- W2032081637 hasConceptScore W2032081637C170493617 @default.
- W2032081637 hasConceptScore W2032081637C181199279 @default.
- W2032081637 hasConceptScore W2032081637C185592680 @default.
- W2032081637 hasConceptScore W2032081637C18903297 @default.
- W2032081637 hasConceptScore W2032081637C197957613 @default.
- W2032081637 hasConceptScore W2032081637C2777289219 @default.
- W2032081637 hasConceptScore W2032081637C2779268744 @default.
- W2032081637 hasConceptScore W2032081637C2779461342 @default.
- W2032081637 hasConceptScore W2032081637C41183919 @default.
- W2032081637 hasConceptScore W2032081637C55493867 @default.
- W2032081637 hasConceptScore W2032081637C71240020 @default.
- W2032081637 hasConceptScore W2032081637C86756495 @default.
- W2032081637 hasConceptScore W2032081637C86803240 @default.
- W2032081637 hasIssue "44" @default.
- W2032081637 hasLocation W20320816371 @default.
- W2032081637 hasLocation W20320816372 @default.
- W2032081637 hasOpenAccess W2032081637 @default.
- W2032081637 hasPrimaryLocation W20320816371 @default.
- W2032081637 hasRelatedWork W1550634984 @default.
- W2032081637 hasRelatedWork W1992557878 @default.
- W2032081637 hasRelatedWork W2021694330 @default.
- W2032081637 hasRelatedWork W2032081637 @default.
- W2032081637 hasRelatedWork W2038109234 @default.
- W2032081637 hasRelatedWork W2083545094 @default.
- W2032081637 hasRelatedWork W2122255780 @default.
- W2032081637 hasRelatedWork W2152381643 @default.
- W2032081637 hasRelatedWork W2158401745 @default.
- W2032081637 hasRelatedWork W3112607042 @default.
- W2032081637 hasVolume "46" @default.
- W2032081637 isParatext "false" @default.
- W2032081637 isRetracted "false" @default.
- W2032081637 magId "2032081637" @default.
- W2032081637 workType "article" @default.