FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032082741> ?p ?o ?g. }

• W2032082741 endingPage "A90" @default.
• W2032082741 startingPage "A90.2" @default.
• W2032082741 abstract "<h3>Aims</h3> Vitamin B12 deficiency is likely to be more common in the paediatric population than previously recognised. Previous associations of neurodevelopmental status and vitamin B12 deficiency have been well recognised. Our case series of four patients who presented to a NHS Trust, demonstrates a more varied presentation with non-specific manifestations including pancytopaenia, failure to thrive, proteinuria and skin rashes. <h3>Methods</h3> 4 children were identified in the last 5 years with a diagnosis of vitamin B12 deficiency (2006-2011). The age range was 11 months to 15 years. Parameters assessed were presenting symptoms, blood results and response to treatment. <h3>Results</h3> 3 patients were male, 1 was female. Common feature to all was severe pancytopaenia. All patients complained of malaise, lethargy and had pallor. Associated symptoms were of exertional dyspnoea, chest pain, and excessive weight loss (>10 kg/month). One patient was treated for sepsis, a result of her being neutropenic at presentation. Other clinical manifestations were of severe neuro-developmental regression (with associated cranial MRI findings) and pigmentation in one case. Proteinuria was detected in two cases suggesting a possible genetic cause (Imerslund-Grasbeck Syndrome) which presents with selective vitamin B12 malabsorption with proteinuria. Both the mothers of the two younger cases9 (both breastfed), were also found to have vitamin B12 deficiency, thereby suggesting a dietary component. The oldest patient had a good diet, and therefore dietary factors were not felt to contribute. All patients responded to standard treatment with VitB12 injections, with resolution of symptoms. Those due to dietary cause were subsequently treated with oral Vit B12. <h3>Conclusion</h3> The common presentation of all four cases was pancytopaenia with its associated complications. 2 cases were found to have a dietary cause. Interestingly one of these was also suspected to have a genetic origin (Imerslund-Grasbeck). A further case was also suspected but testing was declined. The final patient had Juvenile Pernicious Anaemia, as her Intrinsic Factor antibodies were raised. This case series demonstrates the varied presentation and causes of vitamin B12 deficiency, which is commoner than previously acknowledged. It alerts the Paediatricians to be more aware of Vitamin B12 deficiency; especially in children with pancytopaenia." @default.
• W2032082741 created "2016-06-24" @default.
• W2032082741 creator A5015429271 @default.
• W2032082741 creator A5041209073 @default.
• W2032082741 creator A5067358824 @default.
• W2032082741 date "2012-05-01" @default.
• W2032082741 modified "2023-09-26" @default.
• W2032082741 title "Vitamin B12 deficiency in the paediatric population" @default.
• W2032082741 doi "https://doi.org/10.1136/archdischild-2012-301885.216" @default.
• W2032082741 hasPublicationYear "2012" @default.
• W2032082741 type Work @default.
• W2032082741 sameAs 2032082741 @default.
• W2032082741 citedByCount "0" @default.
• W2032082741 crossrefType "journal-article" @default.
• W2032082741 hasAuthorship W2032082741A5015429271 @default.
• W2032082741 hasAuthorship W2032082741A5041209073 @default.
• W2032082741 hasAuthorship W2032082741A5067358824 @default.
• W2032082741 hasConcept C126322002 @default.
• W2032082741 hasConcept C141071460 @default.
• W2032082741 hasConcept C187212893 @default.
• W2032082741 hasConcept C2776917539 @default.
• W2032082741 hasConcept C2777260799 @default.
• W2032082741 hasConcept C2778124894 @default.
• W2032082741 hasConcept C2779561371 @default.
• W2032082741 hasConcept C2779750884 @default.
• W2032082741 hasConcept C2780091579 @default.
• W2032082741 hasConcept C2780439177 @default.
• W2032082741 hasConcept C2908647359 @default.
• W2032082741 hasConcept C71924100 @default.
• W2032082741 hasConcept C99454951 @default.
• W2032082741 hasConceptScore W2032082741C126322002 @default.
• W2032082741 hasConceptScore W2032082741C141071460 @default.
• W2032082741 hasConceptScore W2032082741C187212893 @default.
• W2032082741 hasConceptScore W2032082741C2776917539 @default.
• W2032082741 hasConceptScore W2032082741C2777260799 @default.
• W2032082741 hasConceptScore W2032082741C2778124894 @default.
• W2032082741 hasConceptScore W2032082741C2779561371 @default.
• W2032082741 hasConceptScore W2032082741C2779750884 @default.
• W2032082741 hasConceptScore W2032082741C2780091579 @default.
• W2032082741 hasConceptScore W2032082741C2780439177 @default.
• W2032082741 hasConceptScore W2032082741C2908647359 @default.
• W2032082741 hasConceptScore W2032082741C71924100 @default.
• W2032082741 hasConceptScore W2032082741C99454951 @default.
• W2032082741 hasIssue "Suppl 1" @default.
• W2032082741 hasLocation W20320827411 @default.
• W2032082741 hasOpenAccess W2032082741 @default.
• W2032082741 hasPrimaryLocation W20320827411 @default.
• W2032082741 hasRelatedWork W1834007910 @default.
• W2032082741 hasRelatedWork W1966497639 @default.
• W2032082741 hasRelatedWork W2032082741 @default.
• W2032082741 hasRelatedWork W2061870141 @default.
• W2032082741 hasRelatedWork W2460323274 @default.
• W2032082741 hasRelatedWork W2480654161 @default.
• W2032082741 hasRelatedWork W2553138248 @default.
• W2032082741 hasRelatedWork W2972339788 @default.
• W2032082741 hasRelatedWork W3111460667 @default.
• W2032082741 hasRelatedWork W4280607712 @default.
• W2032082741 hasVolume "97" @default.
• W2032082741 isParatext "false" @default.
• W2032082741 isRetracted "false" @default.
• W2032082741 magId "2032082741" @default.
• W2032082741 workType "article" @default.