FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032083824> ?p ?o ?g. }

• W2032083824 endingPage "780" @default.
• W2032083824 startingPage "766" @default.
• W2032083824 abstract "Genomic alterations affecting chromosome arm 1q are considered to be an early event in breast carcinogenesis and are correlated with good prognosis for the patients. In the search for new breast cancer susceptibility genes, we focused on three genes from the Regulator of G protein Signaling family clustered on 1q25.3 within the HPC1 region. RGS16, RGSL2, and RGSL1 encode proteins interacting with G proteins and accelerating termination of the G protein signaling. To evaluate the implication of these genes in somatic breast cancer, we analyzed a 154-kb segment at 1q25.3 using allelic imbalance (AI) mapping. A panel of 222 patients diagnosed with primary breast cancer was analyzed using newly identified, intragenic short tandem repeats (STRs). A high rate of AI (>50%) was found across the region and led to the identification of internal chromosomal breakpoints. A detailed mapping of the breakpoints revealed intragenic microdeletions affecting the coding regions of RGSL2, RGSL1, and the regulatory region of RGS16. The promoter region of RGS16 was found to be methylated in 10% of the tumors. A decrease in the RGS16 expression was found in tumors with chromosomal breakpoints, AI, and aberrant methylation. We found a significant association between AI of RGSL2 and localized disease, which correlated with good prognosis for patients with breast cancer. In conclusion, we found the 1q25.3 region to be highly unstable in breast tumors comprising a cluster of chromosomal breakpoints, intragenic microdeletions, frequent allelic imbalance correlating with long metastasis-free survival, and RGS16 promoter methylation affecting the protein expression." @default.
• W2032083824 created "2016-06-24" @default.
• W2032083824 creator A5016538015 @default.
• W2032083824 creator A5073129301 @default.
• W2032083824 creator A5078249002 @default.
• W2032083824 date "2008-06-02" @default.
• W2032083824 modified "2023-10-02" @default.
• W2032083824 title "A fragile site within the HPC1 region at 1q25.3 affecting RGS16, RGSL1, and RGSL2 in human breast carcinomas" @default.
• W2032083824 cites W1968789255 @default.
• W2032083824 cites W1969962178 @default.
• W2032083824 cites W1977233225 @default.
• W2032083824 cites W1989817592 @default.
• W2032083824 cites W1991844533 @default.
• W2032083824 cites W1994969588 @default.
• W2032083824 cites W1997834806 @default.
• W2032083824 cites W2002386355 @default.
• W2032083824 cites W2004855923 @default.
• W2032083824 cites W2009351641 @default.
• W2032083824 cites W2015758781 @default.
• W2032083824 cites W2019310175 @default.
• W2032083824 cites W2023353541 @default.
• W2032083824 cites W2048930740 @default.
• W2032083824 cites W2058148583 @default.
• W2032083824 cites W2061384341 @default.
• W2032083824 cites W2067993067 @default.
• W2032083824 cites W2068542290 @default.
• W2032083824 cites W2076496963 @default.
• W2032083824 cites W2079046307 @default.
• W2032083824 cites W2079390026 @default.
• W2032083824 cites W2082055587 @default.
• W2032083824 cites W2084592288 @default.
• W2032083824 cites W2090037766 @default.
• W2032083824 cites W2092975281 @default.
• W2032083824 cites W2095129853 @default.
• W2032083824 cites W2100545500 @default.
• W2032083824 cites W2100948523 @default.
• W2032083824 cites W2101631220 @default.
• W2032083824 cites W2102482497 @default.
• W2032083824 cites W2119889843 @default.
• W2032083824 cites W2146386420 @default.
• W2032083824 cites W2148838874 @default.
• W2032083824 cites W2148882351 @default.
• W2032083824 cites W2150947139 @default.
• W2032083824 cites W2154152972 @default.
• W2032083824 cites W2166510493 @default.
• W2032083824 doi "https://doi.org/10.1002/gcc.20578" @default.
• W2032083824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18521847" @default.
• W2032083824 hasPublicationYear "2008" @default.
• W2032083824 type Work @default.
• W2032083824 sameAs 2032083824 @default.
• W2032083824 citedByCount "30" @default.
• W2032083824 countsByYear W20320838242012 @default.
• W2032083824 countsByYear W20320838242013 @default.
• W2032083824 countsByYear W20320838242014 @default.
• W2032083824 countsByYear W20320838242015 @default.
• W2032083824 countsByYear W20320838242016 @default.
• W2032083824 countsByYear W20320838242017 @default.
• W2032083824 countsByYear W20320838242018 @default.
• W2032083824 countsByYear W20320838242021 @default.
• W2032083824 countsByYear W20320838242022 @default.
• W2032083824 countsByYear W20320838242023 @default.
• W2032083824 crossrefType "journal-article" @default.
• W2032083824 hasAuthorship W2032083824A5016538015 @default.
• W2032083824 hasAuthorship W2032083824A5073129301 @default.
• W2032083824 hasAuthorship W2032083824A5078249002 @default.
• W2032083824 hasConcept C104317684 @default.
• W2032083824 hasConcept C121608353 @default.
• W2032083824 hasConcept C206936463 @default.
• W2032083824 hasConcept C30481170 @default.
• W2032083824 hasConcept C33288867 @default.
• W2032083824 hasConcept C502942594 @default.
• W2032083824 hasConcept C530470458 @default.
• W2032083824 hasConcept C54355233 @default.
• W2032083824 hasConcept C555283112 @default.
• W2032083824 hasConcept C86803240 @default.
• W2032083824 hasConceptScore W2032083824C104317684 @default.
• W2032083824 hasConceptScore W2032083824C121608353 @default.
• W2032083824 hasConceptScore W2032083824C206936463 @default.
• W2032083824 hasConceptScore W2032083824C30481170 @default.
• W2032083824 hasConceptScore W2032083824C33288867 @default.
• W2032083824 hasConceptScore W2032083824C502942594 @default.
• W2032083824 hasConceptScore W2032083824C530470458 @default.
• W2032083824 hasConceptScore W2032083824C54355233 @default.
• W2032083824 hasConceptScore W2032083824C555283112 @default.
• W2032083824 hasConceptScore W2032083824C86803240 @default.
• W2032083824 hasIssue "9" @default.
• W2032083824 hasLocation W20320838241 @default.
• W2032083824 hasLocation W20320838242 @default.
• W2032083824 hasOpenAccess W2032083824 @default.
• W2032083824 hasPrimaryLocation W20320838241 @default.
• W2032083824 hasRelatedWork W1499339123 @default.
• W2032083824 hasRelatedWork W1991523530 @default.
• W2032083824 hasRelatedWork W2002128513 @default.
• W2032083824 hasRelatedWork W2067409815 @default.
• W2032083824 hasRelatedWork W2117059884 @default.
• W2032083824 hasRelatedWork W2171277769 @default.
• W2032083824 hasRelatedWork W2353390064 @default.
• W2032083824 hasRelatedWork W4323808922 @default.

• next