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• W2032085425 abstract "Reactive oxygen species (ROS) have been implicated as second messengers that activate protein kinase cascades, although the means by which ROS regulate signal transduction remains unclear. In the present study, we show that interleukin 1β (IL1β), H2O2, and sorbitol-induced hyperosmolarity mediate a 5- to10-fold increase in phosphorylation (activation) of the p38 protein kinase in rat primary glial cells as measured by analyses of Western blots using an antibody directed against the dually phosphorylated (active) p38. Additionally, IL1β was found to elicit H2O2 synthesis in these cells. Concurrent with p38 phosphorylation, all three stimulation paradigms caused an inhibition of protein phosphatase activity. Phenyl-tert-butyl nitrone (PBN), a nitrone-based free radical trap and N-acetyl-cysteine (NAC), a thiol reducing agent, were examined for their effects on the phosphorylation of p38 as well as phosphatase activity. Pretreatment of cells with either PBN or NAC at 1.0 mM suppressed IL1β H2O2, and sorbitol-mediated activation of p38 and significantly increased phosphatase activity. These data suggest that ROS, particularly H2O2 , are used as second messenger substances that activate p38 in part via the transient inactivation of regulatory protein phosphatases. J. Neurosci. Res. 55:724–732, 1999. © 1999 Wiley-Liss, Inc." @default.
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• W2032085425 date "1999-03-15" @default.
• W2032085425 modified "2023-09-28" @default.
• W2032085425 title "Redox-sensitive protein phosphatase activity regulates the phosphorylation state of p38 protein kinase in primary astrocyte culture" @default.
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• W2032085425 doi "https://doi.org/10.1002/(sici)1097-4547(19990315)55:6<724::aid-jnr7>3.0.co;2-9" @default.
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