FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032085799> ?p ?o ?g. }

• W2032085799 endingPage "e0003566" @default.
• W2032085799 startingPage "e0003566" @default.
• W2032085799 abstract "Significant insights into the biology of Plasmodium vivax have been gained from the ability to successfully adapt human infections to non-human primates. P. vivax strains grown in monkeys serve as a renewable source of parasites for in vitro and ex vivo experimental studies and functional assays, or for studying in vivo the relapse characteristics, mosquito species compatibilities, drug susceptibility profiles or immune responses towards potential vaccine candidates. Despite the importance of these studies, little is known as to how adaptation to a different host species may influence the genome of P. vivax. In addition, it is unclear whether these monkey-adapted strains consist of a single clonal population of parasites or if they retain the multiclonal complexity commonly observed in field isolates. Here we compare the genome sequences of seven P. vivax strains adapted to New World monkeys with those of six human clinical isolates collected directly in the field. We show that the adaptation of P. vivax parasites to monkey hosts, and their subsequent propagation, did not result in significant modifications of their genome sequence and that these monkey-adapted strains recapitulate the genomic diversity of field isolates. Our analyses also reveal that these strains are not always genetically homogeneous and should be analyzed cautiously. Overall, our study provides a framework to better leverage this important research material and fully utilize this resource for improving our understanding of P. vivax biology." @default.
• W2032085799 created "2016-06-24" @default.
• W2032085799 creator A5022834497 @default.
• W2032085799 creator A5033020637 @default.
• W2032085799 creator A5038574644 @default.
• W2032085799 creator A5073776628 @default.
• W2032085799 date "2015-03-13" @default.
• W2032085799 modified "2023-10-16" @default.
• W2032085799 title "Comparative Analysis of Field-Isolate and Monkey-Adapted Plasmodium vivax Genomes" @default.
• W2032085799 cites W1977845940 @default.
• W2032085799 cites W1984101452 @default.
• W2032085799 cites W2000919804 @default.
• W2032085799 cites W2006756465 @default.
• W2032085799 cites W2007629892 @default.
• W2032085799 cites W2017920156 @default.
• W2032085799 cites W2020764092 @default.
• W2032085799 cites W2024004980 @default.
• W2032085799 cites W2041863951 @default.
• W2032085799 cites W2060196479 @default.
• W2032085799 cites W2065019097 @default.
• W2032085799 cites W2078554713 @default.
• W2032085799 cites W2108234281 @default.
• W2032085799 cites W2121675649 @default.
• W2032085799 cites W2131193064 @default.
• W2032085799 cites W2137862593 @default.
• W2032085799 cites W2146036414 @default.
• W2032085799 cites W2148621849 @default.
• W2032085799 cites W2151383900 @default.
• W2032085799 cites W2154250664 @default.
• W2032085799 cites W2155210705 @default.
• W2032085799 cites W2161535656 @default.
• W2032085799 cites W2164844718 @default.
• W2032085799 cites W2170551349 @default.
• W2032085799 cites W2221131846 @default.
• W2032085799 cites W2321947997 @default.
• W2032085799 doi "https://doi.org/10.1371/journal.pntd.0003566" @default.
• W2032085799 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4358935" @default.
• W2032085799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25768941" @default.
• W2032085799 hasPublicationYear "2015" @default.
• W2032085799 type Work @default.
• W2032085799 sameAs 2032085799 @default.
• W2032085799 citedByCount "21" @default.
• W2032085799 countsByYear W20320857992015 @default.
• W2032085799 countsByYear W20320857992016 @default.
• W2032085799 countsByYear W20320857992017 @default.
• W2032085799 countsByYear W20320857992018 @default.
• W2032085799 countsByYear W20320857992019 @default.
• W2032085799 countsByYear W20320857992020 @default.
• W2032085799 countsByYear W20320857992021 @default.
• W2032085799 countsByYear W20320857992022 @default.
• W2032085799 crossrefType "journal-article" @default.
• W2032085799 hasAuthorship W2032085799A5022834497 @default.
• W2032085799 hasAuthorship W2032085799A5033020637 @default.
• W2032085799 hasAuthorship W2032085799A5038574644 @default.
• W2032085799 hasAuthorship W2032085799A5073776628 @default.
• W2032085799 hasBestOaLocation W20320857991 @default.
• W2032085799 hasConcept C104317684 @default.
• W2032085799 hasConcept C141231307 @default.
• W2032085799 hasConcept C144024400 @default.
• W2032085799 hasConcept C149923435 @default.
• W2032085799 hasConcept C159047783 @default.
• W2032085799 hasConcept C203014093 @default.
• W2032085799 hasConcept C2778048844 @default.
• W2032085799 hasConcept C2778371730 @default.
• W2032085799 hasConcept C2779997623 @default.
• W2032085799 hasConcept C2908647359 @default.
• W2032085799 hasConcept C54355233 @default.
• W2032085799 hasConcept C70721500 @default.
• W2032085799 hasConcept C78458016 @default.
• W2032085799 hasConcept C86803240 @default.
• W2032085799 hasConceptScore W2032085799C104317684 @default.
• W2032085799 hasConceptScore W2032085799C141231307 @default.
• W2032085799 hasConceptScore W2032085799C144024400 @default.
• W2032085799 hasConceptScore W2032085799C149923435 @default.
• W2032085799 hasConceptScore W2032085799C159047783 @default.
• W2032085799 hasConceptScore W2032085799C203014093 @default.
• W2032085799 hasConceptScore W2032085799C2778048844 @default.
• W2032085799 hasConceptScore W2032085799C2778371730 @default.
• W2032085799 hasConceptScore W2032085799C2779997623 @default.
• W2032085799 hasConceptScore W2032085799C2908647359 @default.
• W2032085799 hasConceptScore W2032085799C54355233 @default.
• W2032085799 hasConceptScore W2032085799C70721500 @default.
• W2032085799 hasConceptScore W2032085799C78458016 @default.
• W2032085799 hasConceptScore W2032085799C86803240 @default.
• W2032085799 hasIssue "3" @default.
• W2032085799 hasLocation W20320857991 @default.
• W2032085799 hasLocation W20320857992 @default.
• W2032085799 hasLocation W20320857993 @default.
• W2032085799 hasOpenAccess W2032085799 @default.
• W2032085799 hasPrimaryLocation W20320857991 @default.
• W2032085799 hasRelatedWork W2173972794 @default.
• W2032085799 hasRelatedWork W2415853009 @default.
• W2032085799 hasRelatedWork W2481181036 @default.
• W2032085799 hasRelatedWork W2906462523 @default.
• W2032085799 hasRelatedWork W2980469850 @default.
• W2032085799 hasRelatedWork W3022107540 @default.
• W2032085799 hasRelatedWork W3048726500 @default.
• W2032085799 hasRelatedWork W3173704168 @default.

• next