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- W2032088357 abstract "Acute promyelocytic leukemia was diagnosed in a 48-year-old man; the karyotype was normal, whereas reverse transcriptase polymerase chain reaction (RT-PCR) analysis identified PML/RAR alpha chimeric transcripts of the bcr3 type. Rather unexpectedly, the patient did not respond to alltrans retinoic acid administration; he attained complete remission with conventional chemotherapy and became PML/RAR alpha negative. Two years later, while PML/RAR alpha negative on RT-PCR, he presented with thrombocytopenia. Bone marrow examination was compatible with myelodysplasia of the RAEB type; the karyotype was normal. Then, after 10 months, he developed overt acute myeloid leukemia with PML/RAR alpha negative, French-American-British M2 blasts; karyotypic analysis revealed mosaicism for trisomy 8." @default.
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- W2032088357 date "2000-02-01" @default.
- W2032088357 modified "2023-09-26" @default.
- W2032088357 title "Acute Promyelocytic Leukemia Relapsing into FAB-M2 Acute Myeloid Leukemia with Trisomy 8" @default.
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- W2032088357 doi "https://doi.org/10.1016/s0165-4608(99)00132-6" @default.
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