Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032093021> ?p ?o ?g. }
- W2032093021 endingPage "297" @default.
- W2032093021 startingPage "290" @default.
- W2032093021 abstract "Objectives: We investigated the efficacy and safety of the combination of irinotecan (CPT-11) and S-1 (IRIS regimen) as a first-line treatment in patients with metastatic colorectal cancer. We also evaluated the association between UGT1A1 and CYP2A6 polymorphisms and clinical phenotypes. Methods: The patients received CPT-11 (225 mg/m2) on day 1 and S-1 (80 mg/m2) on days 1–14 every 3 weeks. The association of the UGT1A1 (*6 and *28) and CYP2A6(*4, *7, *9, and *10) polymorphisms with toxicities and efficacy were analyzed. Results: Thirty patients were treated. The overall response rate was 66.7% (95% CI 48.7–84.6). The median time to progression was 7.6 months (95% CI 5.8–9.5). The most common grade 3/4 hematologic and non-hematologic toxicity were neutropenia (53.4%) and diarrhea (16.7%), respectively. The allele frequencies of UGT1A1*6 and *28 were 15.5 and 10.3%, respectively. The frequencies of CYP2A6*4, *7, *9, and *10 were 15.5, 8.6, 29.3, and 3.5%, respectively. Stratification of patients according to the number of UGT1A1*28 and *6 alleles showed a significant correlation between the number of defective alleles and the incidence of grade 3/4 neutropenia. Conclusions: Our results indicate that IRIS is a promising first-line regimen in patients with metastatic colorectal cancer. Severe neutropenia may be associated with interindividual variations in UGT1A1 polymorphisms." @default.
- W2032093021 created "2016-06-24" @default.
- W2032093021 creator A5001328180 @default.
- W2032093021 creator A5005127243 @default.
- W2032093021 creator A5005925636 @default.
- W2032093021 creator A5017195273 @default.
- W2032093021 creator A5022104668 @default.
- W2032093021 creator A5044558998 @default.
- W2032093021 creator A5048561149 @default.
- W2032093021 creator A5050625196 @default.
- W2032093021 creator A5063838757 @default.
- W2032093021 creator A5074350034 @default.
- W2032093021 creator A5074535143 @default.
- W2032093021 creator A5085952795 @default.
- W2032093021 date "2012-01-01" @default.
- W2032093021 modified "2023-10-18" @default.
- W2032093021 title "A Phase II Study of Clinical Outcomes of 3-Week Cycles of Irinotecan and S-1 in Patients with Previously Untreated Metastatic Colorectal Cancer: Influence of theUGT1A1andCYP2A6Polymorphisms on Clinical Activity" @default.
- W2032093021 cites W1499419719 @default.
- W2032093021 cites W1968463676 @default.
- W2032093021 cites W1968703649 @default.
- W2032093021 cites W1970089074 @default.
- W2032093021 cites W1977575240 @default.
- W2032093021 cites W1982728538 @default.
- W2032093021 cites W1990971827 @default.
- W2032093021 cites W1992682163 @default.
- W2032093021 cites W1992918749 @default.
- W2032093021 cites W1993085768 @default.
- W2032093021 cites W2007800090 @default.
- W2032093021 cites W2013960768 @default.
- W2032093021 cites W2021622287 @default.
- W2032093021 cites W2030926861 @default.
- W2032093021 cites W2031436799 @default.
- W2032093021 cites W2031555481 @default.
- W2032093021 cites W2037360831 @default.
- W2032093021 cites W2037756952 @default.
- W2032093021 cites W2039016871 @default.
- W2032093021 cites W2040401100 @default.
- W2032093021 cites W2061132293 @default.
- W2032093021 cites W2065064849 @default.
- W2032093021 cites W2066316757 @default.
- W2032093021 cites W2073131930 @default.
- W2032093021 cites W2077902459 @default.
- W2032093021 cites W2095822339 @default.
- W2032093021 cites W2097117460 @default.
- W2032093021 cites W2102172908 @default.
- W2032093021 cites W2106845199 @default.
- W2032093021 cites W2112727687 @default.
- W2032093021 cites W2118385151 @default.
- W2032093021 cites W2119534563 @default.
- W2032093021 cites W2122517534 @default.
- W2032093021 cites W2127532818 @default.
- W2032093021 cites W2128447158 @default.
- W2032093021 cites W2132545630 @default.
- W2032093021 cites W2139248078 @default.
- W2032093021 cites W2314927739 @default.
- W2032093021 cites W2396646859 @default.
- W2032093021 cites W2586483560 @default.
- W2032093021 doi "https://doi.org/10.1159/000337989" @default.
- W2032093021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22555197" @default.
- W2032093021 hasPublicationYear "2012" @default.
- W2032093021 type Work @default.
- W2032093021 sameAs 2032093021 @default.
- W2032093021 citedByCount "15" @default.
- W2032093021 countsByYear W20320930212013 @default.
- W2032093021 countsByYear W20320930212014 @default.
- W2032093021 countsByYear W20320930212015 @default.
- W2032093021 countsByYear W20320930212016 @default.
- W2032093021 countsByYear W20320930212017 @default.
- W2032093021 countsByYear W20320930212020 @default.
- W2032093021 countsByYear W20320930212022 @default.
- W2032093021 countsByYear W20320930212023 @default.
- W2032093021 crossrefType "journal-article" @default.
- W2032093021 hasAuthorship W2032093021A5001328180 @default.
- W2032093021 hasAuthorship W2032093021A5005127243 @default.
- W2032093021 hasAuthorship W2032093021A5005925636 @default.
- W2032093021 hasAuthorship W2032093021A5017195273 @default.
- W2032093021 hasAuthorship W2032093021A5022104668 @default.
- W2032093021 hasAuthorship W2032093021A5044558998 @default.
- W2032093021 hasAuthorship W2032093021A5048561149 @default.
- W2032093021 hasAuthorship W2032093021A5050625196 @default.
- W2032093021 hasAuthorship W2032093021A5063838757 @default.
- W2032093021 hasAuthorship W2032093021A5074350034 @default.
- W2032093021 hasAuthorship W2032093021A5074535143 @default.
- W2032093021 hasAuthorship W2032093021A5085952795 @default.
- W2032093021 hasConcept C121608353 @default.
- W2032093021 hasConcept C126322002 @default.
- W2032093021 hasConcept C2777063308 @default.
- W2032093021 hasConcept C2780259306 @default.
- W2032093021 hasConcept C2781413609 @default.
- W2032093021 hasConcept C29730261 @default.
- W2032093021 hasConcept C526805850 @default.
- W2032093021 hasConcept C71924100 @default.
- W2032093021 hasConcept C90924648 @default.
- W2032093021 hasConceptScore W2032093021C121608353 @default.
- W2032093021 hasConceptScore W2032093021C126322002 @default.
- W2032093021 hasConceptScore W2032093021C2777063308 @default.
- W2032093021 hasConceptScore W2032093021C2780259306 @default.
- W2032093021 hasConceptScore W2032093021C2781413609 @default.