Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032095089> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2032095089 abstract "The cellular actin cytoskeleton plays a central role in the ability of cells to properly sense, propagate, and respond to external stresses and other mechanical stimuli. The actin binding protein calponin has been previously implicated in actin cytoskeletal regulation and is thought to act as an actin stabilizer, but the mechanism of its function is poorly understood.To investigate the underlying physical mechanism, we studied an in vitro model system of crosslinked actin using bulk rheology. Networks with basic calponin exhibited a delayed onset of strain stiffening (gamma crit) and were able to withstand higher strains (gamma max) and stresses (sigma max) before failing. Using fluorescence microscopy to study the mechanics of single actin filaments, we found that calponin increased the flexibility of actin filaments. Our data are consistent with current models of affine strain behavior in semiflexible polymer networks, suggesting that calponin stabilization of actin networks can be explained by changes in single filament mechanics. Comparisons to computational models indicate that a reduction of persistence length of individual actin filaments is the primary mechanism by which calponin stabilizes actin networks against shear.Representative stress-strain curve shown below:View Large Image | View Hi-Res Image | Download PowerPoint Slide" @default.
- W2032095089 created "2016-06-24" @default.
- W2032095089 creator A5018531083 @default.
- W2032095089 creator A5037096687 @default.
- W2032095089 creator A5038905661 @default.
- W2032095089 creator A5049751856 @default.
- W2032095089 creator A5060030134 @default.
- W2032095089 creator A5077105040 @default.
- W2032095089 date "2014-01-01" @default.
- W2032095089 modified "2023-09-29" @default.
- W2032095089 title "Mechanism of Actin Network Stabilization by Changes in Polymer Flexibility by Calponin" @default.
- W2032095089 doi "https://doi.org/10.1016/j.bpj.2013.11.942" @default.
- W2032095089 hasPublicationYear "2014" @default.
- W2032095089 type Work @default.
- W2032095089 sameAs 2032095089 @default.
- W2032095089 citedByCount "0" @default.
- W2032095089 crossrefType "journal-article" @default.
- W2032095089 hasAuthorship W2032095089A5018531083 @default.
- W2032095089 hasAuthorship W2032095089A5037096687 @default.
- W2032095089 hasAuthorship W2032095089A5038905661 @default.
- W2032095089 hasAuthorship W2032095089A5049751856 @default.
- W2032095089 hasAuthorship W2032095089A5060030134 @default.
- W2032095089 hasAuthorship W2032095089A5077105040 @default.
- W2032095089 hasBestOaLocation W20320950891 @default.
- W2032095089 hasConcept C12554922 @default.
- W2032095089 hasConcept C125705527 @default.
- W2032095089 hasConcept C14228908 @default.
- W2032095089 hasConcept C142669718 @default.
- W2032095089 hasConcept C1491633281 @default.
- W2032095089 hasConcept C151000934 @default.
- W2032095089 hasConcept C185592680 @default.
- W2032095089 hasConcept C189040839 @default.
- W2032095089 hasConcept C192562407 @default.
- W2032095089 hasConcept C2781122658 @default.
- W2032095089 hasConcept C2993400109 @default.
- W2032095089 hasConcept C53195969 @default.
- W2032095089 hasConcept C55493867 @default.
- W2032095089 hasConcept C86803240 @default.
- W2032095089 hasConcept C95444343 @default.
- W2032095089 hasConceptScore W2032095089C12554922 @default.
- W2032095089 hasConceptScore W2032095089C125705527 @default.
- W2032095089 hasConceptScore W2032095089C14228908 @default.
- W2032095089 hasConceptScore W2032095089C142669718 @default.
- W2032095089 hasConceptScore W2032095089C1491633281 @default.
- W2032095089 hasConceptScore W2032095089C151000934 @default.
- W2032095089 hasConceptScore W2032095089C185592680 @default.
- W2032095089 hasConceptScore W2032095089C189040839 @default.
- W2032095089 hasConceptScore W2032095089C192562407 @default.
- W2032095089 hasConceptScore W2032095089C2781122658 @default.
- W2032095089 hasConceptScore W2032095089C2993400109 @default.
- W2032095089 hasConceptScore W2032095089C53195969 @default.
- W2032095089 hasConceptScore W2032095089C55493867 @default.
- W2032095089 hasConceptScore W2032095089C86803240 @default.
- W2032095089 hasConceptScore W2032095089C95444343 @default.
- W2032095089 hasLocation W20320950891 @default.
- W2032095089 hasOpenAccess W2032095089 @default.
- W2032095089 hasPrimaryLocation W20320950891 @default.
- W2032095089 hasRelatedWork W1964454637 @default.
- W2032095089 hasRelatedWork W1973665102 @default.
- W2032095089 hasRelatedWork W1973965271 @default.
- W2032095089 hasRelatedWork W1977985567 @default.
- W2032095089 hasRelatedWork W1983429592 @default.
- W2032095089 hasRelatedWork W1986795092 @default.
- W2032095089 hasRelatedWork W1986966044 @default.
- W2032095089 hasRelatedWork W1993226926 @default.
- W2032095089 hasRelatedWork W1995396100 @default.
- W2032095089 hasRelatedWork W2027459092 @default.
- W2032095089 hasRelatedWork W2071102178 @default.
- W2032095089 hasRelatedWork W2083621748 @default.
- W2032095089 hasRelatedWork W2087734239 @default.
- W2032095089 hasRelatedWork W2102043764 @default.
- W2032095089 hasRelatedWork W2341408485 @default.
- W2032095089 hasRelatedWork W2417723458 @default.
- W2032095089 hasRelatedWork W2591760464 @default.
- W2032095089 hasRelatedWork W2924959781 @default.
- W2032095089 hasRelatedWork W3101111283 @default.
- W2032095089 hasRelatedWork W3186209255 @default.
- W2032095089 isParatext "false" @default.
- W2032095089 isRetracted "false" @default.
- W2032095089 magId "2032095089" @default.
- W2032095089 workType "article" @default.