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- W2032096063 abstract "ife would not be possible with-out communication between thecells and the external environ-ment. This critical capability al-lows cells to monitor the status of theorgans and tissues and to respond toenvironmental threats and opportunities.The process is mediated by a group ofmembrane-bound proteins known as Gprotein-coupled receptors (GPCRs).Each GPCR monitors a specific com-pound or group of compounds and be-comes activated when the target ligand(agonist) occupies the active site. Theactivated GPCR signals the presence ofthe ligand through interaction with a Gprotein that migrates within the intracel-lular medium and directly couples to theactivated GPCR. The process providesreliable signaling with variable amplifi-cation. There are at least 700 GPCRsencoded in the human genome. Despitesignificant biological importance, thestructure and function of most GPCRsare poorly understood, and a high-reso-lution crystal structure of only oneGPCR, the visual pigment rhodopsin,has been reported (1–3). Visual pig-ments are seven transmembrane -heli-cal proteins that bind 11-" @default.
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- W2032096063 date "2003-07-28" @default.
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- W2032096063 title "Perspectives on the counterion switch-induced photoactivation of the G protein-coupled receptor rhodopsin" @default.
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- W2032096063 doi "https://doi.org/10.1073/pnas.1733801100" @default.
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