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• W2032097752 endingPage "352" @default.
• W2032097752 startingPage "336" @default.
• W2032097752 abstract "Embryonic cerebellar, neocortical, and striatal tissues derived from NSE-LacZ transgenic mice were transplanted into the right cerebellar hemisphere of 8- to 10-day-oldLurcheror wild-type mice. Host mice survived for 30–90 days and the transplanted tissue was examined by light microscopy using Nissl staining, X-gal histochemistry, and immunohistochemistry for calcium binding protein and glutamic acid decarboxylase. Transplantation of cerebellar tissue, but not neocortical or striatal progenitors, resulted in robust infiltration of the lurcher mutant host cerebellar cortex by transgenic Purkinje neurons. Deep to the infiltrated molecular layer, the host granular layer was thicker and denser than the mutant granular layer, but transgenic cells did not contribute to the spared granular layer. The host inferior olivary complex consistently exhibited a noticeable bilateral asymmetry in Nissl-stained sections. A quantitative analysis of the olivary complex was performed in 10 90-day-old host mice. The results indicate that the left inferior olivary complex of 90-day-old host mice contained more neurons than the right inferior olive of the host mice and contained more neurons than was observed in 90-day-oldLurchercontrol mice. Analysis by olivary subdivision indicates that increased neuron numbers were present in all subdivisions of the host left inferior olive. These studies confirm the specific attractive effect of the mutant cerebellar cortex on transplanted Purkinje neuron progenitors and indicate that neural transplants may survive the neurodegenerative period to interact with developing host neural systems. The unilateral rescue of Lurcher inferior olivary neurons in cerebellar transplant hosts indicates that transplanted neurons may interact with diseased host neural circuits to reduce transneuronal degeneration in the course of a neurodegenerative disease." @default.
• W2032097752 created "2016-06-24" @default.
• W2032097752 creator A5017238827 @default.
• W2032097752 creator A5056112695 @default.
• W2032097752 creator A5072991014 @default.
• W2032097752 date "1998-12-01" @default.
• W2032097752 modified "2023-09-23" @default.
• W2032097752 title "Transplanted Neurons Alter the Course of Neurodegenerative Disease in Lurcher Mutant Mice" @default.
• W2032097752 cites W1230591978 @default.
• W2032097752 cites W1614823057 @default.
• W2032097752 cites W1850032865 @default.
• W2032097752 cites W1964140255 @default.
• W2032097752 cites W1965795979 @default.
• W2032097752 cites W1966734514 @default.
• W2032097752 cites W1967436035 @default.
• W2032097752 cites W1975858840 @default.
• W2032097752 cites W1976306607 @default.
• W2032097752 cites W1976911841 @default.
• W2032097752 cites W1982093529 @default.
• W2032097752 cites W1983180868 @default.
• W2032097752 cites W1989465872 @default.
• W2032097752 cites W1989530010 @default.
• W2032097752 cites W1990831527 @default.
• W2032097752 cites W1992706512 @default.
• W2032097752 cites W1994265387 @default.
• W2032097752 cites W1995964050 @default.
• W2032097752 cites W1996247222 @default.
• W2032097752 cites W1998474165 @default.
• W2032097752 cites W2000302801 @default.
• W2032097752 cites W2003708260 @default.
• W2032097752 cites W2005306079 @default.
• W2032097752 cites W2009776092 @default.
• W2032097752 cites W2013460786 @default.
• W2032097752 cites W2016014894 @default.
• W2032097752 cites W2017689311 @default.
• W2032097752 cites W2022662543 @default.
• W2032097752 cites W2023021848 @default.
• W2032097752 cites W2027615361 @default.
• W2032097752 cites W2028296568 @default.
• W2032097752 cites W2028518963 @default.
• W2032097752 cites W2029052961 @default.
• W2032097752 cites W2029101208 @default.
• W2032097752 cites W2029690491 @default.
• W2032097752 cites W2033410250 @default.
• W2032097752 cites W2034743776 @default.
• W2032097752 cites W2036238540 @default.
• W2032097752 cites W2039372127 @default.
• W2032097752 cites W2045270306 @default.
• W2032097752 cites W2049936588 @default.
• W2032097752 cites W2059243663 @default.
• W2032097752 cites W2060386443 @default.
• W2032097752 cites W2063893203 @default.
• W2032097752 cites W2068113891 @default.
• W2032097752 cites W2069601706 @default.
• W2032097752 cites W2071080651 @default.
• W2032097752 cites W2071196953 @default.
• W2032097752 cites W2071808034 @default.
• W2032097752 cites W2073159300 @default.
• W2032097752 cites W2076236957 @default.
• W2032097752 cites W2076581069 @default.
• W2032097752 cites W2076776277 @default.
• W2032097752 cites W2078746872 @default.
• W2032097752 cites W2085866298 @default.
• W2032097752 cites W2087983820 @default.
• W2032097752 cites W2089328257 @default.
• W2032097752 cites W2090912851 @default.
• W2032097752 cites W2093219880 @default.
• W2032097752 cites W2093825399 @default.
• W2032097752 cites W2106875648 @default.
• W2032097752 cites W2131608302 @default.
• W2032097752 cites W2140725183 @default.
• W2032097752 cites W2144199019 @default.
• W2032097752 cites W2154470090 @default.
• W2032097752 cites W2159266781 @default.
• W2032097752 cites W2162679852 @default.
• W2032097752 cites W2164986141 @default.
• W2032097752 cites W993067339 @default.
• W2032097752 doi "https://doi.org/10.1006/exnr.1998.6960" @default.
• W2032097752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9878172" @default.
• W2032097752 hasPublicationYear "1998" @default.
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