Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032097858> ?p ?o ?g. }
- W2032097858 endingPage "75" @default.
- W2032097858 startingPage "65" @default.
- W2032097858 abstract "Cerebral aneurysm (CA) rupture is a major cause of subarachnoid hemorrhage with high morbidity and mortality. Using an animal model, we examined the potential of endothelial colony-forming cells (ECFCs) transfusion on vascular degeneration after CA induction and underlying mechanisms. CA was induced in the right anterior cerebral artery-olfactory artery (ACA/OA) bifurcations in Sprague-Dawley rats with or without ECFCs transfusion. The degeneration of internal elastic lamina (IEL), media thickness and CA size were evaluated. Expression of matrix metalloproteinase-2 and 9 (MMP-2 and 9), tissue inhibitor of metalloproteinase-1 (TIMP-1), macrophage chemoattractant protein-1 (MCP-1), vascular cell adhesion molecule-1 (VCAM-1), nuclear factor κB (NF-κB), endothelial nitric oxide synthase (eNOS), B-cell leukemia/lymphoma-2 (Bcl-2), and inducible nitric oxide synthase (iNOS) were analyzed by quantitative real-time polymerase chain reaction. The macrophages infiltration and apoptosis of smooth muscle cells (SMCs) were examined immunohistologically. Rats in CA+ECFCs transfusion group showed a notable reduction in IEL degeneration, media thinning and CA size compared with those in CA+saline group. ECFCs transfusion inhibited the MMP-driven wall destruction by downregulating MMP-2, MMP-9 expression and upregulating TIMP-1. ECFCs transfusion dramatically decreased VCAM-1 and NF-κB expression, increased eNOS expression and caused no change in MCP-1 expression, which was accompanied by reduced macrophages infiltration. Moreover, ECFCs transfusion reversed downregulation of Bcl-2 expression and upregulation of iNOS expression, and decreased SMCs apoptosis. Collectively, these findings suggest that ECFCs transfusion confers protection against degeneration of aneurysmal wall by inhibiting inflammatory cascades and SMCs apoptosis." @default.
- W2032097858 created "2016-06-24" @default.
- W2032097858 creator A5006630986 @default.
- W2032097858 creator A5008976260 @default.
- W2032097858 creator A5038446428 @default.
- W2032097858 creator A5052137237 @default.
- W2032097858 creator A5052485047 @default.
- W2032097858 creator A5056125182 @default.
- W2032097858 creator A5066453211 @default.
- W2032097858 creator A5068967433 @default.
- W2032097858 creator A5084666312 @default.
- W2032097858 date "2014-12-01" @default.
- W2032097858 modified "2023-10-18" @default.
- W2032097858 title "Intravenous transfusion of endothelial colony-forming cells attenuates vascular degeneration after cerebral aneurysm induction" @default.
- W2032097858 cites W1528885426 @default.
- W2032097858 cites W1557671060 @default.
- W2032097858 cites W1849785625 @default.
- W2032097858 cites W1957977387 @default.
- W2032097858 cites W1973585594 @default.
- W2032097858 cites W1975292043 @default.
- W2032097858 cites W1978026596 @default.
- W2032097858 cites W1979745959 @default.
- W2032097858 cites W1981575189 @default.
- W2032097858 cites W1981791750 @default.
- W2032097858 cites W1983509308 @default.
- W2032097858 cites W2006139398 @default.
- W2032097858 cites W2015228770 @default.
- W2032097858 cites W2015630918 @default.
- W2032097858 cites W2019029118 @default.
- W2032097858 cites W2022757974 @default.
- W2032097858 cites W2024224971 @default.
- W2032097858 cites W2025299174 @default.
- W2032097858 cites W2025921854 @default.
- W2032097858 cites W2035183737 @default.
- W2032097858 cites W2039196850 @default.
- W2032097858 cites W2039420330 @default.
- W2032097858 cites W2040591047 @default.
- W2032097858 cites W2042680814 @default.
- W2032097858 cites W2048406207 @default.
- W2032097858 cites W2048554615 @default.
- W2032097858 cites W2055959665 @default.
- W2032097858 cites W2059487790 @default.
- W2032097858 cites W2062768752 @default.
- W2032097858 cites W2063152480 @default.
- W2032097858 cites W2063887943 @default.
- W2032097858 cites W2064918830 @default.
- W2032097858 cites W2072341206 @default.
- W2032097858 cites W2074647360 @default.
- W2032097858 cites W2075928902 @default.
- W2032097858 cites W2076118659 @default.
- W2032097858 cites W2084980989 @default.
- W2032097858 cites W2091612277 @default.
- W2032097858 cites W2108287070 @default.
- W2032097858 cites W2112200720 @default.
- W2032097858 cites W2124654004 @default.
- W2032097858 cites W2128033981 @default.
- W2032097858 cites W2130090864 @default.
- W2032097858 cites W2133647080 @default.
- W2032097858 cites W2142799499 @default.
- W2032097858 cites W2145524503 @default.
- W2032097858 cites W2150619987 @default.
- W2032097858 cites W2151702327 @default.
- W2032097858 cites W2158147889 @default.
- W2032097858 cites W2160814598 @default.
- W2032097858 cites W2161322164 @default.
- W2032097858 cites W2324841714 @default.
- W2032097858 cites W2336489200 @default.
- W2032097858 cites W2469889472 @default.
- W2032097858 cites W38263198 @default.
- W2032097858 cites W4237813902 @default.
- W2032097858 cites W4252102346 @default.
- W2032097858 doi "https://doi.org/10.1016/j.brainres.2014.09.077" @default.
- W2032097858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25316629" @default.
- W2032097858 hasPublicationYear "2014" @default.
- W2032097858 type Work @default.
- W2032097858 sameAs 2032097858 @default.
- W2032097858 citedByCount "21" @default.
- W2032097858 countsByYear W20320978582015 @default.
- W2032097858 countsByYear W20320978582016 @default.
- W2032097858 countsByYear W20320978582017 @default.
- W2032097858 countsByYear W20320978582018 @default.
- W2032097858 countsByYear W20320978582019 @default.
- W2032097858 countsByYear W20320978582020 @default.
- W2032097858 countsByYear W20320978582021 @default.
- W2032097858 countsByYear W20320978582022 @default.
- W2032097858 countsByYear W20320978582023 @default.
- W2032097858 crossrefType "journal-article" @default.
- W2032097858 hasAuthorship W2032097858A5006630986 @default.
- W2032097858 hasAuthorship W2032097858A5008976260 @default.
- W2032097858 hasAuthorship W2032097858A5038446428 @default.
- W2032097858 hasAuthorship W2032097858A5052137237 @default.
- W2032097858 hasAuthorship W2032097858A5052485047 @default.
- W2032097858 hasAuthorship W2032097858A5056125182 @default.
- W2032097858 hasAuthorship W2032097858A5066453211 @default.
- W2032097858 hasAuthorship W2032097858A5068967433 @default.
- W2032097858 hasAuthorship W2032097858A5084666312 @default.
- W2032097858 hasConcept C104317684 @default.
- W2032097858 hasConcept C109523444 @default.