FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032098659> ?p ?o ?g. }

• W2032098659 abstract "Nerve growth factor (NGF) is a well-characterized protein that exerts pharmacological effects on a group of cholinergic neurons known to atrophy in Alzheimer's disease (AD). Considerable evidence from animal studies suggests that NGF may be useful in reversing, halting, or at least slowing the progression of AD-related cholinergic basal forebrain atrophy, perhaps even attenuating the cognitive deficit associated with the disorder. However, many questions remain concerning the role of NGF in AD. Levels of the low-affinity receptor for NGF appear to be at least stable in AD basal forebrain, and the recent finding of AD-related increases in cortical NGF brings into question whether endogenous NGF levels are related to the observed cholinergic atrophy and whether additional NGF will be useful in treating this disorder. Evidence regarding the localization of NGF within the central nervous system and its presumed role in maintaining basal forebrain cholinergic neurons is summarized, followed by a synopsis of the relevant aspects of AD neuropathology. The available data regarding levels of NGF and its receptor in the AD brain, as well as potential roles for NGF in the pathogenesis and treatment of AD, are also reviewed. NGF and its low affinity receptor are abundantly present within the AD brain, although this does not rule out an NGF-related mechanism in the degeneration of basal forebrain neurons, nor does it eliminate the possibility that exogenous NGF may be successfully used to treat AD. Further studies of the degree and distribution of NGF within the human brain in normal aging and in AD, and of the possible relationship between target NGF levels and the status of basal forebrain neurons in vivo, are necessary before engaging in clinical trials." @default.
• W2032098659 created "2016-06-24" @default.
• W2032098659 creator A5020827112 @default.
• W2032098659 creator A5036632785 @default.
• W2032098659 date "1994-01-01" @default.
• W2032098659 modified "2023-09-25" @default.
• W2032098659 title "Nerve Growth Factor and Alzheimer's Disease" @default.
• W2032098659 cites W1493358526 @default.
• W2032098659 cites W1497131246 @default.
• W2032098659 cites W1527035699 @default.
• W2032098659 cites W1539302044 @default.
• W2032098659 cites W1547573021 @default.
• W2032098659 cites W1550759106 @default.
• W2032098659 cites W1552108068 @default.
• W2032098659 cites W1565785673 @default.
• W2032098659 cites W1569576869 @default.
• W2032098659 cites W1572212128 @default.
• W2032098659 cites W1576690422 @default.
• W2032098659 cites W1593177105 @default.
• W2032098659 cites W1597356000 @default.
• W2032098659 cites W1602968629 @default.
• W2032098659 cites W1606587171 @default.
• W2032098659 cites W1609471181 @default.
• W2032098659 cites W1639832183 @default.
• W2032098659 cites W1673416974 @default.
• W2032098659 cites W1820424262 @default.
• W2032098659 cites W1840016921 @default.
• W2032098659 cites W1860556713 @default.
• W2032098659 cites W1898295630 @default.
• W2032098659 cites W1941281848 @default.
• W2032098659 cites W1963808816 @default.
• W2032098659 cites W1964363963 @default.
• W2032098659 cites W1965072630 @default.
• W2032098659 cites W1965250235 @default.
• W2032098659 cites W1965835251 @default.
• W2032098659 cites W1966019489 @default.
• W2032098659 cites W1966157184 @default.
• W2032098659 cites W1966370755 @default.
• W2032098659 cites W1967211332 @default.
• W2032098659 cites W1967511986 @default.
• W2032098659 cites W1968515623 @default.
• W2032098659 cites W1968633705 @default.
• W2032098659 cites W1968634235 @default.
• W2032098659 cites W1968713362 @default.
• W2032098659 cites W1969099021 @default.
• W2032098659 cites W1969423869 @default.
• W2032098659 cites W1969457796 @default.
• W2032098659 cites W1970483015 @default.
• W2032098659 cites W1971032362 @default.
• W2032098659 cites W1971117140 @default.
• W2032098659 cites W1971986023 @default.
• W2032098659 cites W1972706594 @default.
• W2032098659 cites W1972988863 @default.
• W2032098659 cites W1973238216 @default.
• W2032098659 cites W1973531344 @default.
• W2032098659 cites W1973619130 @default.
• W2032098659 cites W1974028432 @default.
• W2032098659 cites W1974094027 @default.
• W2032098659 cites W1974179395 @default.
• W2032098659 cites W1974607544 @default.
• W2032098659 cites W1975204261 @default.
• W2032098659 cites W1975256554 @default.
• W2032098659 cites W1975384687 @default.
• W2032098659 cites W1975972443 @default.
• W2032098659 cites W1975982276 @default.
• W2032098659 cites W1976035276 @default.
• W2032098659 cites W1976536444 @default.
• W2032098659 cites W1976774853 @default.
• W2032098659 cites W1976845082 @default.
• W2032098659 cites W1977405586 @default.
• W2032098659 cites W1977609103 @default.
• W2032098659 cites W1977656398 @default.
• W2032098659 cites W1977767090 @default.
• W2032098659 cites W1978274895 @default.
• W2032098659 cites W1978348817 @default.
• W2032098659 cites W1978575001 @default.
• W2032098659 cites W1978817724 @default.
• W2032098659 cites W1979060829 @default.
• W2032098659 cites W1980505845 @default.
• W2032098659 cites W1980910954 @default.
• W2032098659 cites W1981726318 @default.
• W2032098659 cites W1981919520 @default.
• W2032098659 cites W1982064952 @default.
• W2032098659 cites W1982202183 @default.
• W2032098659 cites W1982371579 @default.
• W2032098659 cites W1982719361 @default.
• W2032098659 cites W1983386636 @default.
• W2032098659 cites W1983556790 @default.
• W2032098659 cites W1983806125 @default.
• W2032098659 cites W1984156600 @default.
• W2032098659 cites W1984178229 @default.
• W2032098659 cites W1984218330 @default.
• W2032098659 cites W1984420254 @default.
• W2032098659 cites W1984907449 @default.
• W2032098659 cites W1985221567 @default.
• W2032098659 cites W1985402554 @default.
• W2032098659 cites W1985722204 @default.
• W2032098659 cites W1985822867 @default.
• W2032098659 cites W1985995922 @default.
• W2032098659 cites W1986792985 @default.

• next