Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032099211> ?p ?o ?g. }
- W2032099211 endingPage "331" @default.
- W2032099211 startingPage "326" @default.
- W2032099211 abstract "Purpose of review Regulatory T cells (Tregs) are potential therapeutic tools in averting transplant rejection and promoting lifelong tolerance. However, Tregs can be subverted by inflammatory conditions, resulting in a T helper 17 (Th17) cell response. This review looks at the relationship between Tregs and Th17 cells. Recent findings Both naturally occurring and transforming growth factor-β-induced Tregs can be converted into Th17 cells in the presence of inflammatory cytokines. Transforming growth factor-β upregulates the Treg transcription factor, forkhead box P3, as well as the Th17 transcription factor, retinoic acid receptor-related orphan receptor γ. However, forkhead box P3 binds to retinoic acid receptor-related orphan receptor γ, inhibiting its promotion of IL-17 gene transcription. Inflammatory cytokines can disrupt this interaction through the inhibition of forkhead box P3 expression by signal transducer and activator of transcription 3. Summary The plasticity of the Treg population during inflammation presents a challenge to the use of Tregs as a therapeutic tool in solid organ transplantation. Investigations into the Th17–Treg axis have identified a number of potential pharmacological targets to avoid the risk of conversion to Th17 cells, but further work must be done before we can separate the benefits of Treg therapy from the hazards of the Th17 response." @default.
- W2032099211 created "2016-06-24" @default.
- W2032099211 creator A5010690912 @default.
- W2032099211 creator A5019533207 @default.
- W2032099211 creator A5040147848 @default.
- W2032099211 creator A5042602459 @default.
- W2032099211 date "2009-08-01" @default.
- W2032099211 modified "2023-10-15" @default.
- W2032099211 title "The T helper 17–regulatory T cell axis in transplant rejection and tolerance" @default.
- W2032099211 cites W1520953238 @default.
- W2032099211 cites W1527011538 @default.
- W2032099211 cites W1531876501 @default.
- W2032099211 cites W1878828051 @default.
- W2032099211 cites W1899583926 @default.
- W2032099211 cites W1924258068 @default.
- W2032099211 cites W1964465182 @default.
- W2032099211 cites W1965206234 @default.
- W2032099211 cites W1982243301 @default.
- W2032099211 cites W1982926364 @default.
- W2032099211 cites W2012680181 @default.
- W2032099211 cites W2019077533 @default.
- W2032099211 cites W2025492877 @default.
- W2032099211 cites W2031551895 @default.
- W2032099211 cites W2034337172 @default.
- W2032099211 cites W2037259928 @default.
- W2032099211 cites W2041512435 @default.
- W2032099211 cites W2042586707 @default.
- W2032099211 cites W2043500875 @default.
- W2032099211 cites W2043776488 @default.
- W2032099211 cites W2044063309 @default.
- W2032099211 cites W2045763435 @default.
- W2032099211 cites W2049518790 @default.
- W2032099211 cites W2051018333 @default.
- W2032099211 cites W2051615464 @default.
- W2032099211 cites W2058950182 @default.
- W2032099211 cites W2060905466 @default.
- W2032099211 cites W2070323372 @default.
- W2032099211 cites W2073672027 @default.
- W2032099211 cites W2077492907 @default.
- W2032099211 cites W2084786488 @default.
- W2032099211 cites W2085321949 @default.
- W2032099211 cites W2087967190 @default.
- W2032099211 cites W2093283349 @default.
- W2032099211 cites W2097931810 @default.
- W2032099211 cites W2110178990 @default.
- W2032099211 cites W2112866067 @default.
- W2032099211 cites W2113297797 @default.
- W2032099211 cites W2114273138 @default.
- W2032099211 cites W2115779634 @default.
- W2032099211 cites W2118736569 @default.
- W2032099211 cites W2120010406 @default.
- W2032099211 cites W2125573161 @default.
- W2032099211 cites W2126463172 @default.
- W2032099211 cites W2126487427 @default.
- W2032099211 cites W2131977720 @default.
- W2032099211 cites W2135498185 @default.
- W2032099211 cites W2136707854 @default.
- W2032099211 cites W2150505180 @default.
- W2032099211 cites W2155779547 @default.
- W2032099211 cites W2156177776 @default.
- W2032099211 cites W2160836190 @default.
- W2032099211 cites W2161329415 @default.
- W2032099211 cites W2166282414 @default.
- W2032099211 cites W2167297937 @default.
- W2032099211 cites W2171531113 @default.
- W2032099211 doi "https://doi.org/10.1097/mot.0b013e32832ce88e" @default.
- W2032099211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19448538" @default.
- W2032099211 hasPublicationYear "2009" @default.
- W2032099211 type Work @default.
- W2032099211 sameAs 2032099211 @default.
- W2032099211 citedByCount "83" @default.
- W2032099211 countsByYear W20320992112012 @default.
- W2032099211 countsByYear W20320992112013 @default.
- W2032099211 countsByYear W20320992112014 @default.
- W2032099211 countsByYear W20320992112015 @default.
- W2032099211 countsByYear W20320992112016 @default.
- W2032099211 countsByYear W20320992112017 @default.
- W2032099211 countsByYear W20320992112018 @default.
- W2032099211 countsByYear W20320992112019 @default.
- W2032099211 countsByYear W20320992112020 @default.
- W2032099211 countsByYear W20320992112021 @default.
- W2032099211 countsByYear W20320992112022 @default.
- W2032099211 countsByYear W20320992112023 @default.
- W2032099211 crossrefType "journal-article" @default.
- W2032099211 hasAuthorship W2032099211A5010690912 @default.
- W2032099211 hasAuthorship W2032099211A5019533207 @default.
- W2032099211 hasAuthorship W2032099211A5040147848 @default.
- W2032099211 hasAuthorship W2032099211A5042602459 @default.
- W2032099211 hasConcept C104317684 @default.
- W2032099211 hasConcept C120197328 @default.
- W2032099211 hasConcept C171958077 @default.
- W2032099211 hasConcept C203014093 @default.
- W2032099211 hasConcept C2778923194 @default.
- W2032099211 hasConcept C2779161069 @default.
- W2032099211 hasConcept C2779727006 @default.
- W2032099211 hasConcept C2781121885 @default.
- W2032099211 hasConcept C2908647359 @default.
- W2032099211 hasConcept C502942594 @default.