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- W2032112650 abstract "The Wnt/beta-catenin signal transduction pathway regulates a broad range of developmental processes. Aberrant activation of the Wnt pathway leads to cancer and degenerative diseases. beta-catenin is a key signaling molecule that is frequently used as a direct monitor of Wnt pathway activation. This paper describes a multi-parametric method for quantitative analysis of cellular beta-catenin protein levels in a rapid and high-throughput manner. The assay offers temporally resolved detection of Wnt-stimulated accumulation of beta-catenin, simultaneously detecting cell number, and it sheds light onto the kinetics of posttranslational stabilization of beta-catenin." @default.
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- W2032112650 title "Kinetics of Wnt-Driven β-Catenin Stabilization Revealed by Quantitative and Temporal Imaging" @default.
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- W2032112650 doi "https://doi.org/10.1371/journal.pone.0003498" @default.
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