Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032117788> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2032117788 endingPage "293" @default.
- W2032117788 startingPage "287" @default.
- W2032117788 abstract "The effects of sodium phenobarbital and sodium barbital on the activity of the particulate and cytosolic 5α-dihydroprogesterone 3α-hydroxysteroid oxidoreductases (3α-HSORs) of female rat anterior pituitary were investigated. By altering the 3α-HSOR catalyzed conversion of 5α-dihydroprogesterone (5α-DHP) to 3α,5α-tetrahydroprogesterone (3α,5α-THP), these barbiturates could influence the in situ production of 3α,5α-THP. 3α,5α-THP has potent barbiturate-like effects on brain GABAA receptors. Both phenobarbital and 3α,5α-THP can affect gonadotropin release in female rats. In vitro incubations of each 3α-HSOR activity were assayed in the presence of sodium phenobarbital (0.1 to 10.0 mM) or sodium barbital (1.0 to 10.0 mM). Since both 3α-HSOR activities catalyze the reversible oxidoreduction of 5α-DHP and 3α,5α-THP, we examined the effect of these barbiturates not only on the conversion of 5α-DHP to 3α,5α-THP (reductive reaction) but also on the “back conversion” of 3α,5α-THP to 5α-DHP (oxidative reaction). The results indicate that both phenobarbital and, to a lesser extent barbital, significantly affected the activities of the two 3α-HSORs in both reductive and oxidative directions. In the reductive direction, phenobarbital inhibited the activity (33%) of both cytosolic and particulate enzymes which would presumably decrease the levels of 3α,5α-THP. In the oxidative direction, a pattern of stimulation was observed (20 to 100%). Thus, this stimulatory effect on the oxidative conversion of 3α,5α-THP to 5α-DHP, which would presumably also decrease 3α,5α-THP levels, appears correlated with the inhibitory effect of these barbiturates on the reductive conversion of 5α-DHP to 3α,5α-THP. Sodium barbital exhibited somewhat similar effects. These changes suggest that barbiturates can lower 3α,5α-THP levels in the anterior pituitary. The results also suggest the possibility that lowered 3α,5α-THP levels may be involved, at least in part, in the reduction of gonadotropin release by barbiturates." @default.
- W2032117788 created "2016-06-24" @default.
- W2032117788 creator A5015125341 @default.
- W2032117788 creator A5067874853 @default.
- W2032117788 date "1993-04-01" @default.
- W2032117788 modified "2023-09-27" @default.
- W2032117788 title "Barbiturates modulate the activity of the pituitary 3α-hydroxysteroid oxidoreductases and inhibit their production of 3α,5α-tetrahydroprogesterone" @default.
- W2032117788 cites W2006442321 @default.
- W2032117788 cites W2011057906 @default.
- W2032117788 cites W2023238131 @default.
- W2032117788 cites W2063439191 @default.
- W2032117788 cites W2070403289 @default.
- W2032117788 cites W2083447043 @default.
- W2032117788 cites W2087652180 @default.
- W2032117788 cites W2148176139 @default.
- W2032117788 cites W2157264338 @default.
- W2032117788 cites W2163961809 @default.
- W2032117788 cites W4245117662 @default.
- W2032117788 cites W43526258 @default.
- W2032117788 doi "https://doi.org/10.1016/0960-0760(93)90344-v" @default.
- W2032117788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8499336" @default.
- W2032117788 hasPublicationYear "1993" @default.
- W2032117788 type Work @default.
- W2032117788 sameAs 2032117788 @default.
- W2032117788 citedByCount "2" @default.
- W2032117788 crossrefType "journal-article" @default.
- W2032117788 hasAuthorship W2032117788A5015125341 @default.
- W2032117788 hasAuthorship W2032117788A5067874853 @default.
- W2032117788 hasConcept C126322002 @default.
- W2032117788 hasConcept C134018914 @default.
- W2032117788 hasConcept C185592680 @default.
- W2032117788 hasConcept C2778793413 @default.
- W2032117788 hasConcept C2780077838 @default.
- W2032117788 hasConcept C2780193516 @default.
- W2032117788 hasConcept C2780276229 @default.
- W2032117788 hasConcept C2780902042 @default.
- W2032117788 hasConcept C2780957381 @default.
- W2032117788 hasConcept C43617362 @default.
- W2032117788 hasConcept C55493867 @default.
- W2032117788 hasConcept C57600042 @default.
- W2032117788 hasConcept C71315377 @default.
- W2032117788 hasConcept C71924100 @default.
- W2032117788 hasConcept C86803240 @default.
- W2032117788 hasConcept C98274493 @default.
- W2032117788 hasConceptScore W2032117788C126322002 @default.
- W2032117788 hasConceptScore W2032117788C134018914 @default.
- W2032117788 hasConceptScore W2032117788C185592680 @default.
- W2032117788 hasConceptScore W2032117788C2778793413 @default.
- W2032117788 hasConceptScore W2032117788C2780077838 @default.
- W2032117788 hasConceptScore W2032117788C2780193516 @default.
- W2032117788 hasConceptScore W2032117788C2780276229 @default.
- W2032117788 hasConceptScore W2032117788C2780902042 @default.
- W2032117788 hasConceptScore W2032117788C2780957381 @default.
- W2032117788 hasConceptScore W2032117788C43617362 @default.
- W2032117788 hasConceptScore W2032117788C55493867 @default.
- W2032117788 hasConceptScore W2032117788C57600042 @default.
- W2032117788 hasConceptScore W2032117788C71315377 @default.
- W2032117788 hasConceptScore W2032117788C71924100 @default.
- W2032117788 hasConceptScore W2032117788C86803240 @default.
- W2032117788 hasConceptScore W2032117788C98274493 @default.
- W2032117788 hasIssue "4" @default.
- W2032117788 hasLocation W20321177881 @default.
- W2032117788 hasLocation W20321177882 @default.
- W2032117788 hasOpenAccess W2032117788 @default.
- W2032117788 hasPrimaryLocation W20321177881 @default.
- W2032117788 hasRelatedWork W1968299024 @default.
- W2032117788 hasRelatedWork W1983493846 @default.
- W2032117788 hasRelatedWork W2045295079 @default.
- W2032117788 hasRelatedWork W2078470363 @default.
- W2032117788 hasRelatedWork W2092034319 @default.
- W2032117788 hasRelatedWork W2112223211 @default.
- W2032117788 hasRelatedWork W2141847421 @default.
- W2032117788 hasRelatedWork W2189267764 @default.
- W2032117788 hasRelatedWork W2399792076 @default.
- W2032117788 hasRelatedWork W2433967449 @default.
- W2032117788 hasVolume "45" @default.
- W2032117788 isParatext "false" @default.
- W2032117788 isRetracted "false" @default.
- W2032117788 magId "2032117788" @default.
- W2032117788 workType "article" @default.