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- W2032131359 endingPage "R5" @default.
- W2032131359 startingPage "R5" @default.
- W2032131359 abstract "Radial chromosome positioning in interphase nuclei is nonrandom and can alter according to developmental, differentiation, proliferation, or disease status. However, it is not yet clear when and how chromosome repositioning is elicited. By investigating the positioning of all human chromosomes in primary fibroblasts that have left the proliferative cell cycle, we have demonstrated that in cells made quiescent by reversible growth arrest, chromosome positioning is altered considerably. We found that with the removal of serum from the culture medium, chromosome repositioning took less than 15 minutes, required energy and was inhibited by drugs affecting the polymerization of myosin and actin. We also observed that when cells became quiescent, the nuclear distribution of nuclear myosin 1β was dramatically different from that in proliferating cells. If we suppressed the expression of nuclear myosin 1β by using RNA-interference procedures, the movement of chromosomes after 15 minutes in low serum was inhibited. When high serum was restored to the serum-starved cultures, chromosome repositioning was evident only after 24 to 36 hours, and this coincided with a return to a proliferating distribution of nuclear myosin 1β. These findings demonstrate that genome organization in interphase nuclei is altered considerably when cells leave the proliferative cell cycle and that repositioning of chromosomes relies on efficient functioning of an active nuclear motor complex that contains nuclear myosin 1β." @default.
- W2032131359 created "2016-06-24" @default.
- W2032131359 creator A5053186593 @default.
- W2032131359 creator A5064543356 @default.
- W2032131359 creator A5075401534 @default.
- W2032131359 creator A5081641761 @default.
- W2032131359 date "2010-01-01" @default.
- W2032131359 modified "2023-10-12" @default.
- W2032131359 title "Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts" @default.
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- W2032131359 doi "https://doi.org/10.1186/gb-2010-11-1-r5" @default.
- W2032131359 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2847717" @default.
- W2032131359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20070886" @default.
- W2032131359 hasPublicationYear "2010" @default.
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