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• W2032150432 endingPage "344" @default.
• W2032150432 startingPage "334" @default.
• W2032150432 abstract "Proteins with seven transmembrane segments (7TM) define a superfamily of receptors (7TM receptors) sharing the same topology: an extracellular N-terminus, three extramembranous loops on either side of the plasma membrane, and a cytoplasmic C-terminal tail. Upon ligand binding, cytoplasmic portions of the activated receptor interact with heterotrimeric G-coupled proteins to induce various second messengers. A small group, recently recognized on the basis of homologous primary amino acid sequences, comprises receptors to hormones of the secretin/vasoactive intestinal peptide/glucagon family, parathyroid hormone and parathyroid hormone-related peptides, growth hormone-releasing factor, corticotropin-releasing factor, and calcitonin. A cDNA, extracted from a neuroectodermal cDNA library, was predicted to encode a new 886-amino-acid protein with three distinct domains. The C-terminal third contains the seven hydrophobic segments and characteristic residues that allow the protein to be readily aligned with the various hormone receptors in the family. Six egf-like modules, at the N-terminus of the predicted mature protein, are separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Because of its unique characteristics, this putative egf module-containing, mucin-like hormone receptor has been named EMR1. Southern analysis of a panel of somatic cell hybrids and fluorescence in situ hybridization have assigned the EMR1 gene to human chromosome 19p13.3." @default.
• W2032150432 created "2016-06-24" @default.
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• W2032150432 date "1995-03-01" @default.
• W2032150432 modified "2023-10-15" @default.
• W2032150432 title "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments" @default.
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• W2032150432 doi "https://doi.org/10.1016/0888-7543(95)80218-b" @default.
• W2032150432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7601460" @default.
• W2032150432 hasPublicationYear "1995" @default.
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