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• W2032156685 startingPage "342" @default.
• W2032156685 abstract "A thorough experimental and computational study of derivatives of (3-sec-butyl-2,3-dihydroisoquinolin-4-ylidene)acetic acid was performed. Some of these compounds are calpain inhibitors and could be useful as therapeutic agents, since this enzyme is a Ca2+-dependent cysteine protease involved in a wide variety of metabolic and physiological processes, whose over-activation is associated to several pathological conditions. To gain a better understanding of the structure−activity relationships, a structural analysis was carried out with 1H and 13C NMR spectroscopy and DFT calculations together with the X-ray diffraction data of three compounds. The solid state structures showed that the crystal packing as well as the intermolecular interactions depend on the substituent nature of the COOR group. Also, the reactivity of the exocyclic double bond was theoretically evaluated, finding that the more reactive compound is the most potent inhibitor of calpain (IC50 = 25 nM)." @default.
• W2032156685 created "2016-06-24" @default.
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• W2032156685 date "2009-12-16" @default.
• W2032156685 modified "2023-10-12" @default.
• W2032156685 title "X-ray Diffraction, Solution Structure, and Computational Studies on Derivatives of (3-<i>sec</i>-Butyl-2,3-dihydro-1<i>H</i>-isoquinolin-4-ylidene)acetic Acid: Compounds with Activity as Calpain Inhibitors" @default.
• W2032156685 cites W1969885133 @default.
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• W2032156685 cites W1987756203 @default.
• W2032156685 cites W1988599801 @default.
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• W2032156685 doi "https://doi.org/10.1021/jo902091u" @default.
• W2032156685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20014819" @default.
• W2032156685 hasPublicationYear "2009" @default.
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