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- W2032158341 abstract "Ilicicolin H is a broad spectrum antifungal agent showing sub micro g/mL MICs against Candida spp., Aspergillus fumigatus and Cryptococcus spp. It is a potent inhibitor (C50 2–3 ng/mL) of the mitochondrial cytochrome bc1 reductase with over 1000-fold selectivity against rat liver cytochrome bc1 reductase. Structure–activity relationship of semisynthetic derivatives by chemical modification of ilicicolin H and its 19-hydroxy derivative produced by biotransformation have been described. Basic 4′-esters and moderately polar N- and O-alkyl derivatives retained antifungal and the cytochrome bc1 reductase activities. 4′,19-Diacetate and 19-cyclopropyl acetate retained antifungal and enzyme activity and selectivity with over 20-fold improvement of plasma protein binding." @default.
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- W2032158341 date "2013-05-01" @default.
- W2032158341 modified "2023-09-27" @default.
- W2032158341 title "Structure–activity relationship of cytochrome bc1 reductase inhibitor broad spectrum antifungal ilicicolin H" @default.
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- W2032158341 doi "https://doi.org/10.1016/j.bmcl.2013.03.023" @default.
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