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• W2032171907 abstract "CD8+/Leu-7+ T cells which circulate in increased proportions in the blood of long-term surviving BMT patients are for the most part high-density resting lymphocytes lacking IL2R-α (p55) expression. We show that they can be induced by IL2 to manifest cytolytic function after 24–48 hr stimulation by using rather high concentrations of IL2 (at least 50 U/ml). This function was much more readily induced in high-density CD8+/Leu-7+ T cells than in high-density CD8+/Leu-7− T cells and occurred in the presence of minimal cell proliferation. Other cytokines involved in primary CTL differentiation (IFN-γ, IL4 and IL6) were without effect suggesting that CD8+/Leu-7+ T cells are, in the BMT model, in vivo preactivated CTL ready to differentiate into cytolytic effectors under the sole IL2 stimulus. TU27 Mab directed at IL2R-β (p75) subunit almost completely prevented IL2-induced cytolytic function of CD8+ T cells while 33B3.1 Mab directed at IL2R-α (p55) subunit was ineffective, suggesting that the signal for this function has its origin in IL2R-β chains constitutively expressed by these cells." @default.
• W2032171907 created "2016-06-24" @default.
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• W2032171907 date "1990-10-01" @default.
• W2032171907 modified "2023-10-18" @default.
• W2032171907 title "Induction of cytolytic function in resting peripheral blood CD8+/ Leu-7+ T cells through IL2/p 75 IL2-receptor interaction: A study in the allogeneic human bone marrow transplantation model" @default.
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• W2032171907 doi "https://doi.org/10.1016/0008-8749(90)90272-s" @default.
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• W2032171907 hasPublicationYear "1990" @default.
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